Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-[beta] signalling: implications for PAH vascular remodelling

Excessive TGF-[beta] signalling has been shown to underlie pulmonary hypertension (PAH). Human pulmonary artery smooth muscle cells (HPASMCs) can release extracellular vesicles (EVs) but their contents and significance have not yet been studied. Here, we aimed to analyse the contents and biological...

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Veröffentlicht in:	Cell communication and signaling 2019-11, Vol.17 (1)
Hauptverfasser:	de la Cuesta, Fernando, Passalacqua, Ilaria, Rodor, Julie, Bhushan, Raghu, Denby, Laura, Baker, Andrew H
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Bone morphogenetic proteins Endothelium Genes Hypertension Messenger RNA Muscle proteins Pulmonary hypertension RNA RNA sequencing Scientific equipment industry Smooth muscle Technology Transforming growth factors Translation (Genetics)
Online-Zugang:	Volltext
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