Study on Diagnostic Values of Astrocyte Elevated Gene 1 in Hepatocellular Carcinoma

Study on Diagnostic Values of Astrocyte Elevated Gene 1 in Hepatocellular Carcinoma

Objectives: To investigate the diagnostic potential of AEG-1 and GPC-3 in hepatocellular carcinoma (HCC). Methods: AEG-1 and GPC-3 immunohistochemistry were performed on HCC, adjacent nontumor tissue (ANT), and dysplastic nodules (DN). Results: H score of AEG-1 or GPC-3 in HCC was significantly high...

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Veröffentlicht in:American journal of clinical pathology 2019-11, Vol.152 (5), p.647
Hauptverfasser: Cao, Wenqing, Sharma, Meenal, Imam, Rami, Yu, Jiangzhou
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Sprache:eng
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Diagnosis
Diagnosis, Differential
Hepatoma
Methods
Oncogenes
Proteoglycans
Testing
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container_title American journal of clinical pathology
container_volume 152
creator Cao, Wenqing
Sharma, Meenal
Imam, Rami
Yu, Jiangzhou
description Objectives: To investigate the diagnostic potential of AEG-1 and GPC-3 in hepatocellular carcinoma (HCC). Methods: AEG-1 and GPC-3 immunohistochemistry were performed on HCC, adjacent nontumor tissue (ANT), and dysplastic nodules (DN). Results: H score of AEG-1 or GPC-3 in HCC was significantly higher than in ANT or DN. In HCC, 92% and 54% showed AEG-1 and GPC-3 positivity, respectively. In ANT, 16.2% were AEG-1 and 7.6% GPC-3 positive. AEG-1 staining was mostly diffuse, whereas GPC-3 frequently showed focal staining. AEG-1 alone showed high sensitivity but low specificity and accuracy. GPC-3, on the other hand, showed high specificity but low sensitivity and accuracy. Combination of both stains boosted the sensitivity, specificity, and accuracy to 94.6%, 89.5%, and 90.5%, respectively, when only diffuse staining was considered as positive. Conclusions: AEG-1 or GPC-3 alone seemed not an ideal marker for HCC. The combination of AEG-1 and GPC-3 might improve early diagnosis of HCC. Key Words: AEG-1; GPC-3; Hepatocellular carcinoma; Diagnosis
doi_str_mv 10.1093/AJCP/AQZ086
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Methods: AEG-1 and GPC-3 immunohistochemistry were performed on HCC, adjacent nontumor tissue (ANT), and dysplastic nodules (DN). Results: H score of AEG-1 or GPC-3 in HCC was significantly higher than in ANT or DN. In HCC, 92% and 54% showed AEG-1 and GPC-3 positivity, respectively. In ANT, 16.2% were AEG-1 and 7.6% GPC-3 positive. AEG-1 staining was mostly diffuse, whereas GPC-3 frequently showed focal staining. AEG-1 alone showed high sensitivity but low specificity and accuracy. GPC-3, on the other hand, showed high specificity but low sensitivity and accuracy. Combination of both stains boosted the sensitivity, specificity, and accuracy to 94.6%, 89.5%, and 90.5%, respectively, when only diffuse staining was considered as positive. Conclusions: AEG-1 or GPC-3 alone seemed not an ideal marker for HCC. The combination of AEG-1 and GPC-3 might improve early diagnosis of HCC. 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Methods: AEG-1 and GPC-3 immunohistochemistry were performed on HCC, adjacent nontumor tissue (ANT), and dysplastic nodules (DN). Results: H score of AEG-1 or GPC-3 in HCC was significantly higher than in ANT or DN. In HCC, 92% and 54% showed AEG-1 and GPC-3 positivity, respectively. In ANT, 16.2% were AEG-1 and 7.6% GPC-3 positive. AEG-1 staining was mostly diffuse, whereas GPC-3 frequently showed focal staining. AEG-1 alone showed high sensitivity but low specificity and accuracy. GPC-3, on the other hand, showed high specificity but low sensitivity and accuracy. Combination of both stains boosted the sensitivity, specificity, and accuracy to 94.6%, 89.5%, and 90.5%, respectively, when only diffuse staining was considered as positive. Conclusions: AEG-1 or GPC-3 alone seemed not an ideal marker for HCC. The combination of AEG-1 and GPC-3 might improve early diagnosis of HCC. 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Methods: AEG-1 and GPC-3 immunohistochemistry were performed on HCC, adjacent nontumor tissue (ANT), and dysplastic nodules (DN). Results: H score of AEG-1 or GPC-3 in HCC was significantly higher than in ANT or DN. In HCC, 92% and 54% showed AEG-1 and GPC-3 positivity, respectively. In ANT, 16.2% were AEG-1 and 7.6% GPC-3 positive. AEG-1 staining was mostly diffuse, whereas GPC-3 frequently showed focal staining. AEG-1 alone showed high sensitivity but low specificity and accuracy. GPC-3, on the other hand, showed high specificity but low sensitivity and accuracy. Combination of both stains boosted the sensitivity, specificity, and accuracy to 94.6%, 89.5%, and 90.5%, respectively, when only diffuse staining was considered as positive. Conclusions: AEG-1 or GPC-3 alone seemed not an ideal marker for HCC. The combination of AEG-1 and GPC-3 might improve early diagnosis of HCC. Key Words: AEG-1; GPC-3; Hepatocellular carcinoma; Diagnosis</abstract><pub>Oxford University Press</pub><doi>10.1093/AJCP/AQZ086</doi></addata></record>
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source Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Diagnosis
Diagnosis, Differential
Hepatoma
Methods
Oncogenes
Proteoglycans
Testing
title Study on Diagnostic Values of Astrocyte Elevated Gene 1 in Hepatocellular Carcinoma
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