Desumoylation of aggrecan and collagen II facilitates degradation via aggrecanases in IL-1[beta]-mediated osteoarthritis

Background: Aggrecan plays a crucial role in the ability of tissues to withstand compressive loads during the pathological progression of osteoarthritis (OA). Progressive loss of aggrecan from cartilage may result in exposure of the collagen matrix and can lead to its disintegration by metalloprotea...

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Veröffentlicht in:	Journal of pain research 2019-07, p.2145
Hauptverfasser:	Zhu, Bing, Cui, Guanxing, Zhang, Qifu, Cheng, Xiankui, Tang, Shusen
Format:	Artikel
Sprache:	eng
Schlagworte:	Collagen Cytokines Fluorescent antibody technique Inflammation Interleukins Messenger RNA Osteoarthritis Polymerase chain reaction Proteases Proteins RNA Ubiquitin
Online-Zugang:	Volltext
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