Myogenic vasoconstriction requires G.sub.12/G.sub.13 and LARG to maintain local and systemic vascular resistance

Myogenic vasoconstriction is an autoregulatory function of small arteries. Recently, G-protein-coupled receptors have been involved in myogenic vasoconstriction, but the downstream signalling mechanisms and the in-vivo-function of this myogenic autoregulation are poorly understood. Here, we show tha...

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Veröffentlicht in:	eLife 2019-09, Vol.8
Hauptverfasser:	Chennupati, Ramesh, Wirth, Angela, Favre, Julie, Li, Rui, Bonnavion, Rémy, Jin, Young-June, Wietelmann, Astrid, Schweda, Frank, Wettschureck, Nina, Henrion, Daniel, Offermanns, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteries Guanine Neural circuitry Observations Physiological aspects Purines Smooth muscle Vasoconstriction
Online-Zugang:	Volltext
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