PTPN2 regulates the generation of exhausted CD8.sup.+ T cell subpopulations and restrains tumor immunity

CD8.sup.+ T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6.sup.+ progenitor exhausted and Tim-3.sup.+ terminally exhausted subpopulations through unknown mechanisms. Here we establish the phosphatase PTPN2 as a new r...

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Veröffentlicht in:	Nature immunology 2019-10, Vol.20 (10), p.1335
Hauptverfasser:	LaFleur, Martin W, Nguyen, Thao H, Coxe, Matthew A, Miller, Brian C, Yates, Kathleen B, Gillis, Jacob E, Sen, Debattama R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cancer Care and treatment Cellular control mechanisms Health aspects Immunological research Immunotherapy Phosphatases Physiological aspects T cells
Online-Zugang:	Volltext
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