Genetic polymorphisms in PXR and NF-[kappa]B1 influence susceptibility to anti-tuberculosis drug-induced liver injury

Pregnane X receptor (PXR) regulates the expression of drug-metabolizing enzymes and transport enzymes. NF-[kappa]B not only plays a role in liver homeostasis and injury-healing processes by regulating inflammatory responses but may also regulate the transcription of PXR. Currently, genetic polymorph...

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Veröffentlicht in:	PloS one 2019-09, Vol.14 (9), p.e0222033
Hauptverfasser:	Zhang, Jingwei, Zhao, Zhenzhen, Bai, Hao, Wang, Minjin, Jiao, Lin, Peng, Wu, Wu, Tao, Liu, Tangyuheng, Chen, Hao, Song, Xingbo, Wu, Lijuan, Hu, Xuejiao, Wu, Qian, Zhou, Juan, Song, Jiajia, Lyv, Mengyuan, Ying, Binwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antitubercular agents Chromosomes Diagnosis Enzymes Gene expression Genetic aspects Genetic polymorphisms Genetic research Genotypes Homeostasis Inflammation Liver Mycobacterium tuberculosis Nuclear receptors Single nucleotide polymorphisms Transcription (Genetics) Tuberculosis
Online-Zugang:	Volltext
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