Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1[beta], IL-6 and TNF-[alpha] in Spinal Cord of Rats with Bone Cancer Pain

Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1[beta], IL-6 and TNF-[alpha] in Spinal Cord of Rats with Bone Cancer Pain

Objective: To investigate the effects of parecoxib on pain threshold and inflammatory factors interleukin-1[beta] (IL-1[beta]), interleukin-6 (IL-6) and tumor necrosis factor-[alpha] (TNF-[alpha]) in spinal cord of rats with bone cancer pain. Study Design: An experimental study. Place and Duration o...

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Veröffentlicht in:Journal of the College of Physicians and Surgeons--Pakistan 2019-06, Vol.29 (6), p.528
Hauptverfasser: Chen, Jun, Cong, Xiufeng, Zhan, Xiuzhu, Zhou, Zheng, Zheng, Wei
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Sprache:eng
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Bone cancer
Cancer pain
Interleukins
Medical schools
Tumor necrosis factor
Women's health
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container_issue 6
container_start_page 528
container_title Journal of the College of Physicians and Surgeons--Pakistan
container_volume 29
creator Chen, Jun
Cong, Xiufeng
Zhan, Xiuzhu
Zhou, Zheng
Zheng, Wei
description Objective: To investigate the effects of parecoxib on pain threshold and inflammatory factors interleukin-1[beta] (IL-1[beta]), interleukin-6 (IL-6) and tumor necrosis factor-[alpha] (TNF-[alpha]) in spinal cord of rats with bone cancer pain. Study Design: An experimental study. Place and Duration of Study: Department of Oncology, Shengjing Hospital of China Medical University, China, from March 2017 to May 2018. Methodology: Twenty-four healthy female Sprague-Dawley rats were selected and the bone cancer pain model was inoculated with W256 breast cancer cell into the bone marrow. Rats with bone cancer pain were randomly divided into the model group and the parecoxib group on the 7th day postoperation, with 12 rats in each group. Another 12 rats were taken as the control group. Rats in the parecoxib group were given intraperitoneal injection of parecoxib (8 mg/kg) for 10 consecutive days since the 15th day after operation. Mechanical pain threshold, thermal pain threshold, and the levels of inflammatory factors IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of rats in each group were compared. Results: On the 14th postoperative day, mechanical pain threshold and thermal pain threshold of rats in the model group and the parecoxib group were significantly decreased compared with those in the control group (p
doi_str_mv 10.29271/jcpsp.2019.06.528
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Study Design: An experimental study. Place and Duration of Study: Department of Oncology, Shengjing Hospital of China Medical University, China, from March 2017 to May 2018. Methodology: Twenty-four healthy female Sprague-Dawley rats were selected and the bone cancer pain model was inoculated with W256 breast cancer cell into the bone marrow. Rats with bone cancer pain were randomly divided into the model group and the parecoxib group on the 7th day postoperation, with 12 rats in each group. Another 12 rats were taken as the control group. Rats in the parecoxib group were given intraperitoneal injection of parecoxib (8 mg/kg) for 10 consecutive days since the 15th day after operation. Mechanical pain threshold, thermal pain threshold, and the levels of inflammatory factors IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of rats in each group were compared. Results: On the 14th postoperative day, mechanical pain threshold and thermal pain threshold of rats in the model group and the parecoxib group were significantly decreased compared with those in the control group (p&lt;0.001). After 5 and 10 days of administration, mechanical and thermal pain threshold of rats in the parecoxib group were significantly higher than those in the model group and the control group (p&lt;0.001). After 10 days of administration, levels of IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of the model group were higher than those of the control group (p&lt;0.001); and levels of IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of the parecoxib group were significantly lower than those in the model group and the control group (p&lt;0.001). Conclusion: Parecoxib can alleviate hyperalgesia in rats with bone cancer pain, increase pain threshold and inhibit the up-regulation of inflammatory factors in the spinal cord. Parecoxib may achieve analgesic effects by down-regulating the expression of IL-1[beta], IL-6 and TNF-[alpha] in the spinal cord. Key Words: Parecoxib, Bone cancer pain, Rat, Analgesia, IL-1[beta], IL-6, TNF-[alpha].</description><identifier>ISSN: 1022-386X</identifier><identifier>DOI: 10.29271/jcpsp.2019.06.528</identifier><language>eng</language><publisher>College of Physicians and Surgeons Pakistan</publisher><subject>Bone cancer ; Cancer pain ; Interleukins ; Medical schools ; Tumor necrosis factor ; Women's health</subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2019-06, Vol.29 (6), p.528</ispartof><rights>COPYRIGHT 2019 College of Physicians and Surgeons Pakistan</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Cong, Xiufeng</creatorcontrib><creatorcontrib>Zhan, Xiuzhu</creatorcontrib><creatorcontrib>Zhou, Zheng</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><title>Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1[beta], IL-6 and TNF-[alpha] in Spinal Cord of Rats with Bone Cancer Pain</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><description>Objective: To investigate the effects of parecoxib on pain threshold and inflammatory factors interleukin-1[beta] (IL-1[beta]), interleukin-6 (IL-6) and tumor necrosis factor-[alpha] (TNF-[alpha]) in spinal cord of rats with bone cancer pain. Study Design: An experimental study. Place and Duration of Study: Department of Oncology, Shengjing Hospital of China Medical University, China, from March 2017 to May 2018. Methodology: Twenty-four healthy female Sprague-Dawley rats were selected and the bone cancer pain model was inoculated with W256 breast cancer cell into the bone marrow. Rats with bone cancer pain were randomly divided into the model group and the parecoxib group on the 7th day postoperation, with 12 rats in each group. Another 12 rats were taken as the control group. Rats in the parecoxib group were given intraperitoneal injection of parecoxib (8 mg/kg) for 10 consecutive days since the 15th day after operation. Mechanical pain threshold, thermal pain threshold, and the levels of inflammatory factors IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of rats in each group were compared. Results: On the 14th postoperative day, mechanical pain threshold and thermal pain threshold of rats in the model group and the parecoxib group were significantly decreased compared with those in the control group (p&lt;0.001). After 5 and 10 days of administration, mechanical and thermal pain threshold of rats in the parecoxib group were significantly higher than those in the model group and the control group (p&lt;0.001). After 10 days of administration, levels of IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of the model group were higher than those of the control group (p&lt;0.001); and levels of IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of the parecoxib group were significantly lower than those in the model group and the control group (p&lt;0.001). Conclusion: Parecoxib can alleviate hyperalgesia in rats with bone cancer pain, increase pain threshold and inhibit the up-regulation of inflammatory factors in the spinal cord. Parecoxib may achieve analgesic effects by down-regulating the expression of IL-1[beta], IL-6 and TNF-[alpha] in the spinal cord. Key Words: Parecoxib, Bone cancer pain, Rat, Analgesia, IL-1[beta], IL-6, TNF-[alpha].</description><subject>Bone cancer</subject><subject>Cancer pain</subject><subject>Interleukins</subject><subject>Medical schools</subject><subject>Tumor necrosis factor</subject><subject>Women's health</subject><issn>1022-386X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjk1Lw0AQhvegYK3-AU8LXk3cj2yye6zBaqGoaAWhlDLdjyYl2YRsQP0R_mfT6sGDzOGdGd55n0HogpKYKZbR651uQxszQlVM0lgweYRGlDAWcZm-naDTEHaEcEGlHKGvW-es7gNuHH6Czurmo9zgxg9D6fGi6Gwomspg8AbPvKugrqFvuk88BT1owLN5RJcb28Pqat-nB-fiYRotoWoLWOEh5qUtPVQ4bzqz5zzDwHsv-wLfNN7iHLy23QF4ho4dVMGe_-oYvU5vF_l9NH-8m-WTebSlPOujVIAzWhhhuFDGMGtTKRUHpbSQTlJNGSeMEp5sMq0kU1wniXGZSTMNJON8jC5_crdQ2XXpXdN3oOsy6PVEKEJZyhIxuOJ_XEMZW5d6eN2Vw_7PwTftrXLj</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Chen, Jun</creator><creator>Cong, Xiufeng</creator><creator>Zhan, Xiuzhu</creator><creator>Zhou, Zheng</creator><creator>Zheng, Wei</creator><general>College of Physicians and Surgeons Pakistan</general><scope/></search><sort><creationdate>20190601</creationdate><title>Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1[beta], IL-6 and TNF-[alpha] in Spinal Cord of Rats with Bone Cancer Pain</title><author>Chen, Jun ; Cong, Xiufeng ; Zhan, Xiuzhu ; Zhou, Zheng ; Zheng, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g137t-65afdc5d5d359dd2ee68893a99c58f81c123021034b7c98293c44df7d67ca0733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bone cancer</topic><topic>Cancer pain</topic><topic>Interleukins</topic><topic>Medical schools</topic><topic>Tumor necrosis factor</topic><topic>Women's health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Cong, Xiufeng</creatorcontrib><creatorcontrib>Zhan, Xiuzhu</creatorcontrib><creatorcontrib>Zhou, Zheng</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jun</au><au>Cong, Xiufeng</au><au>Zhan, Xiuzhu</au><au>Zhou, Zheng</au><au>Zheng, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1[beta], IL-6 and TNF-[alpha] in Spinal Cord of Rats with Bone Cancer Pain</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><date>2019-06-01</date><risdate>2019</risdate><volume>29</volume><issue>6</issue><spage>528</spage><pages>528-</pages><issn>1022-386X</issn><abstract>Objective: To investigate the effects of parecoxib on pain threshold and inflammatory factors interleukin-1[beta] (IL-1[beta]), interleukin-6 (IL-6) and tumor necrosis factor-[alpha] (TNF-[alpha]) in spinal cord of rats with bone cancer pain. Study Design: An experimental study. Place and Duration of Study: Department of Oncology, Shengjing Hospital of China Medical University, China, from March 2017 to May 2018. Methodology: Twenty-four healthy female Sprague-Dawley rats were selected and the bone cancer pain model was inoculated with W256 breast cancer cell into the bone marrow. Rats with bone cancer pain were randomly divided into the model group and the parecoxib group on the 7th day postoperation, with 12 rats in each group. Another 12 rats were taken as the control group. Rats in the parecoxib group were given intraperitoneal injection of parecoxib (8 mg/kg) for 10 consecutive days since the 15th day after operation. Mechanical pain threshold, thermal pain threshold, and the levels of inflammatory factors IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of rats in each group were compared. Results: On the 14th postoperative day, mechanical pain threshold and thermal pain threshold of rats in the model group and the parecoxib group were significantly decreased compared with those in the control group (p&lt;0.001). After 5 and 10 days of administration, mechanical and thermal pain threshold of rats in the parecoxib group were significantly higher than those in the model group and the control group (p&lt;0.001). After 10 days of administration, levels of IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of the model group were higher than those of the control group (p&lt;0.001); and levels of IL-1[beta], IL-6 and TNF-[alpha] in spinal cord of the parecoxib group were significantly lower than those in the model group and the control group (p&lt;0.001). Conclusion: Parecoxib can alleviate hyperalgesia in rats with bone cancer pain, increase pain threshold and inhibit the up-regulation of inflammatory factors in the spinal cord. Parecoxib may achieve analgesic effects by down-regulating the expression of IL-1[beta], IL-6 and TNF-[alpha] in the spinal cord. Key Words: Parecoxib, Bone cancer pain, Rat, Analgesia, IL-1[beta], IL-6, TNF-[alpha].</abstract><pub>College of Physicians and Surgeons Pakistan</pub><doi>10.29271/jcpsp.2019.06.528</doi></addata></record>
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subjects Bone cancer
Cancer pain
Interleukins
Medical schools
Tumor necrosis factor
Women's health
title Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1[beta], IL-6 and TNF-[alpha] in Spinal Cord of Rats with Bone Cancer Pain
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