Is Regular Screening for Intracranial Aneurysm Necessary in Patients with Autosomal Dominant Polycystic Kidney Disease? A Systematic Review and Meta-analysis
Background: The prevalence of intracranial aneurysm in patients with autosomal dominant polycystic kidney disease (ADPKD) is higher than that among the general population. We performed a systematic review and meta-analysis on the prevalence and natural history of intracranial aneurysm among patients...
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| Veröffentlicht in: | Cerebrovascular diseases (Basel, Switzerland) Switzerland), 2017-08, Vol.44 (1-2), p.75-82 |
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| creator | Zhou, Zien Xu, Ying Delcourt, Candice Shan, Jiehui Li, Qiang Xu, Jianrong Hackett, Maree L. |
| description | Background: The prevalence of intracranial aneurysm in patients with autosomal dominant polycystic kidney disease (ADPKD) is higher than that among the general population. We performed a systematic review and meta-analysis on the prevalence and natural history of intracranial aneurysm among patients with ADPKD. Methods: Medline, Embase, Web of Science and Scopus, from inception to July 2016, were searched for studies reporting the occurrence of intracranial aneurysms among participants with ADPKD. Two authors independently assessed the eligibility of all retrieved studies and extracted data. Information on the prevalence of intracranial aneurysms and their natural history in participants with ADPKD was collected from all included studies. Results: Fifteen studies with 1,490 participants with ADPKD were pooled to study about the prevalence of intracranial aneurysm in participants with ADPKD, and the prevalence rate was found to be 10% (95% CI 7-13%). Studies from China, Japan and Europe (Germany, Poland) reported a higher prevalence of intracranial aneurysm. Having a family history of haemorrhagic stroke or intracranial aneurysm was a risk factor for aneurysm occurrence. Twenty-three percent (95% CI 15-31%) of the participants had multiple aneurysms. Most of the aneurysms were small ( |
| doi_str_mv | 10.1159/000476073 |
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A Systematic Review and Meta-analysis</title><source>MEDLINE</source><source>Karger Journals</source><creator>Zhou, Zien ; Xu, Ying ; Delcourt, Candice ; Shan, Jiehui ; Li, Qiang ; Xu, Jianrong ; Hackett, Maree L.</creator><creatorcontrib>Zhou, Zien ; Xu, Ying ; Delcourt, Candice ; Shan, Jiehui ; Li, Qiang ; Xu, Jianrong ; Hackett, Maree L.</creatorcontrib><description>Background: The prevalence of intracranial aneurysm in patients with autosomal dominant polycystic kidney disease (ADPKD) is higher than that among the general population. We performed a systematic review and meta-analysis on the prevalence and natural history of intracranial aneurysm among patients with ADPKD. Methods: Medline, Embase, Web of Science and Scopus, from inception to July 2016, were searched for studies reporting the occurrence of intracranial aneurysms among participants with ADPKD. Two authors independently assessed the eligibility of all retrieved studies and extracted data. Information on the prevalence of intracranial aneurysms and their natural history in participants with ADPKD was collected from all included studies. Results: Fifteen studies with 1,490 participants with ADPKD were pooled to study about the prevalence of intracranial aneurysm in participants with ADPKD, and the prevalence rate was found to be 10% (95% CI 7-13%). Studies from China, Japan and Europe (Germany, Poland) reported a higher prevalence of intracranial aneurysm. Having a family history of haemorrhagic stroke or intracranial aneurysm was a risk factor for aneurysm occurrence. Twenty-three percent (95% CI 15-31%) of the participants had multiple aneurysms. Most of the aneurysms were small (<6 mm) and located in the anterior circulation. Five studies with 171 participants (83 with 106 aneurysms at baseline and 88 without) were analyzed to understand the natural history of aneurysms, with an incidence of aneurysm growth, new aneurysm and aneurysm rupture of 1.84% (followed up for 435 person-years), 0.57% (1,227 person-years) and 0.13% (792 person-years) respectively. Conclusions: Screening for intracranial aneurysm is recommended in patients with ADPKD when there is a family history of haemorrhagic stroke or intracranial aneurysm and when they are from China, Japan or Europe (Germany, Poland). Based on existing data, regular imaging follow-up is not supported. High-quality, prospective studies are needed in the future.</description><identifier>ISSN: 1015-9770</identifier><identifier>EISSN: 1421-9786</identifier><identifier>DOI: 10.1159/000476073</identifier><identifier>PMID: 28502970</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Aneurysm ; Anopheles ; Cerebral aneurysm ; Cerebral Angiography - methods ; Diagnostic imaging ; Female ; Humans ; Intracranial Aneurysm - diagnostic imaging ; Intracranial Aneurysm - epidemiology ; Kidney diseases ; Magnetic Resonance Angiography ; Male ; Medical research ; Middle Aged ; Odds Ratio ; Patient Selection ; Polycystic kidney disease ; Polycystic Kidney, Autosomal Dominant - diagnosis ; Polycystic Kidney, Autosomal Dominant - epidemiology ; Predictive Value of Tests ; Prevalence ; Prognosis ; Review ; Risk Assessment ; Risk Factors ; Stroke ; Time Factors</subject><ispartof>Cerebrovascular diseases (Basel, Switzerland), 2017-08, Vol.44 (1-2), p.75-82</ispartof><rights>2017 S. Karger AG, Basel</rights><rights>2017 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2017 S. Karger AG</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-59dc9cf47993dbe4254e99763606eb3fe4017278cf10dcddb95befe12c026a2a3</citedby><cites>FETCH-LOGICAL-c467t-59dc9cf47993dbe4254e99763606eb3fe4017278cf10dcddb95befe12c026a2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28502970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Zien</creatorcontrib><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Delcourt, Candice</creatorcontrib><creatorcontrib>Shan, Jiehui</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Xu, Jianrong</creatorcontrib><creatorcontrib>Hackett, Maree L.</creatorcontrib><title>Is Regular Screening for Intracranial Aneurysm Necessary in Patients with Autosomal Dominant Polycystic Kidney Disease? A Systematic Review and Meta-analysis</title><title>Cerebrovascular diseases (Basel, Switzerland)</title><addtitle>Cerebrovasc Dis</addtitle><description>Background: The prevalence of intracranial aneurysm in patients with autosomal dominant polycystic kidney disease (ADPKD) is higher than that among the general population. We performed a systematic review and meta-analysis on the prevalence and natural history of intracranial aneurysm among patients with ADPKD. Methods: Medline, Embase, Web of Science and Scopus, from inception to July 2016, were searched for studies reporting the occurrence of intracranial aneurysms among participants with ADPKD. Two authors independently assessed the eligibility of all retrieved studies and extracted data. Information on the prevalence of intracranial aneurysms and their natural history in participants with ADPKD was collected from all included studies. Results: Fifteen studies with 1,490 participants with ADPKD were pooled to study about the prevalence of intracranial aneurysm in participants with ADPKD, and the prevalence rate was found to be 10% (95% CI 7-13%). Studies from China, Japan and Europe (Germany, Poland) reported a higher prevalence of intracranial aneurysm. Having a family history of haemorrhagic stroke or intracranial aneurysm was a risk factor for aneurysm occurrence. Twenty-three percent (95% CI 15-31%) of the participants had multiple aneurysms. Most of the aneurysms were small (<6 mm) and located in the anterior circulation. Five studies with 171 participants (83 with 106 aneurysms at baseline and 88 without) were analyzed to understand the natural history of aneurysms, with an incidence of aneurysm growth, new aneurysm and aneurysm rupture of 1.84% (followed up for 435 person-years), 0.57% (1,227 person-years) and 0.13% (792 person-years) respectively. Conclusions: Screening for intracranial aneurysm is recommended in patients with ADPKD when there is a family history of haemorrhagic stroke or intracranial aneurysm and when they are from China, Japan or Europe (Germany, Poland). Based on existing data, regular imaging follow-up is not supported. High-quality, prospective studies are needed in the future.</description><subject>Adult</subject><subject>Aged</subject><subject>Aneurysm</subject><subject>Anopheles</subject><subject>Cerebral aneurysm</subject><subject>Cerebral Angiography - methods</subject><subject>Diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Intracranial Aneurysm - diagnostic imaging</subject><subject>Intracranial Aneurysm - epidemiology</subject><subject>Kidney diseases</subject><subject>Magnetic Resonance Angiography</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Patient Selection</subject><subject>Polycystic kidney disease</subject><subject>Polycystic Kidney, Autosomal Dominant - diagnosis</subject><subject>Polycystic Kidney, Autosomal Dominant - epidemiology</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Review</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Time Factors</subject><issn>1015-9770</issn><issn>1421-9786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0ktvEzEQAOAVAtEHHLgjZAkJwWGLvU_7hKKkQESBqoXzymvPJoZdO3i8rfbH8F9xlBCoVPlgy_ONrbEnSZ4xesZYKd5SSou6onX-IDlmRcZSUfPqYVxTVsZ1TY-SE8QfkVWMs8fJUcZLmomaHie_l0iuYDX20pNr5QGssSvSOU-WNnipvLRG9mRmYfQTDuQLKECUfiLGkksZDNiA5NaENZmNwaEbol64wVhpA7l0_aQmDEaRT0ZbmMjCIEiEd2RGrmMABrkNXsGNgVsirSafIchUWtlPaPBJ8qiTPcLT_XyafH9__m3-Mb34-mE5n12kqqjqkJZCK6G6ohYi1y0UWVmAEHWVV7SCNu-goKzOaq46RrXSuhVlCx2wTNGskpnMT5PXu3M33v0aAUMzGFTQ99KCG7FhXAhGuajKSF_u6Er20Bjbue0zbXkzKzkXXJS8iursHhWHhsEoZ6Ezcf9Owqv_EtYg-7BG14_BOIt34ZsdVN4heuiajTdD_JCG0WbbDc2hG6J9sS9rbAfQB_n3-_8V81P6FfgDmJ8vdkc0G91F9fxetb_lD-H3xKM</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Zhou, Zien</creator><creator>Xu, Ying</creator><creator>Delcourt, Candice</creator><creator>Shan, Jiehui</creator><creator>Li, Qiang</creator><creator>Xu, Jianrong</creator><creator>Hackett, Maree L.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Is Regular Screening for Intracranial Aneurysm Necessary in Patients with Autosomal Dominant Polycystic Kidney Disease? A Systematic Review and Meta-analysis</title><author>Zhou, Zien ; Xu, Ying ; Delcourt, Candice ; Shan, Jiehui ; Li, Qiang ; Xu, Jianrong ; Hackett, Maree L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-59dc9cf47993dbe4254e99763606eb3fe4017278cf10dcddb95befe12c026a2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aneurysm</topic><topic>Anopheles</topic><topic>Cerebral aneurysm</topic><topic>Cerebral Angiography - methods</topic><topic>Diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Intracranial Aneurysm - diagnostic imaging</topic><topic>Intracranial Aneurysm - epidemiology</topic><topic>Kidney diseases</topic><topic>Magnetic Resonance Angiography</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Patient Selection</topic><topic>Polycystic kidney disease</topic><topic>Polycystic Kidney, Autosomal Dominant - diagnosis</topic><topic>Polycystic Kidney, Autosomal Dominant - epidemiology</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Review</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Zien</creatorcontrib><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Delcourt, Candice</creatorcontrib><creatorcontrib>Shan, Jiehui</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Xu, Jianrong</creatorcontrib><creatorcontrib>Hackett, Maree L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebrovascular diseases (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Zien</au><au>Xu, Ying</au><au>Delcourt, Candice</au><au>Shan, Jiehui</au><au>Li, Qiang</au><au>Xu, Jianrong</au><au>Hackett, Maree L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is Regular Screening for Intracranial Aneurysm Necessary in Patients with Autosomal Dominant Polycystic Kidney Disease? A Systematic Review and Meta-analysis</atitle><jtitle>Cerebrovascular diseases (Basel, Switzerland)</jtitle><addtitle>Cerebrovasc Dis</addtitle><date>2017-08</date><risdate>2017</risdate><volume>44</volume><issue>1-2</issue><spage>75</spage><epage>82</epage><pages>75-82</pages><issn>1015-9770</issn><eissn>1421-9786</eissn><abstract>Background: The prevalence of intracranial aneurysm in patients with autosomal dominant polycystic kidney disease (ADPKD) is higher than that among the general population. We performed a systematic review and meta-analysis on the prevalence and natural history of intracranial aneurysm among patients with ADPKD. Methods: Medline, Embase, Web of Science and Scopus, from inception to July 2016, were searched for studies reporting the occurrence of intracranial aneurysms among participants with ADPKD. Two authors independently assessed the eligibility of all retrieved studies and extracted data. Information on the prevalence of intracranial aneurysms and their natural history in participants with ADPKD was collected from all included studies. Results: Fifteen studies with 1,490 participants with ADPKD were pooled to study about the prevalence of intracranial aneurysm in participants with ADPKD, and the prevalence rate was found to be 10% (95% CI 7-13%). Studies from China, Japan and Europe (Germany, Poland) reported a higher prevalence of intracranial aneurysm. Having a family history of haemorrhagic stroke or intracranial aneurysm was a risk factor for aneurysm occurrence. Twenty-three percent (95% CI 15-31%) of the participants had multiple aneurysms. Most of the aneurysms were small (<6 mm) and located in the anterior circulation. Five studies with 171 participants (83 with 106 aneurysms at baseline and 88 without) were analyzed to understand the natural history of aneurysms, with an incidence of aneurysm growth, new aneurysm and aneurysm rupture of 1.84% (followed up for 435 person-years), 0.57% (1,227 person-years) and 0.13% (792 person-years) respectively. Conclusions: Screening for intracranial aneurysm is recommended in patients with ADPKD when there is a family history of haemorrhagic stroke or intracranial aneurysm and when they are from China, Japan or Europe (Germany, Poland). Based on existing data, regular imaging follow-up is not supported. High-quality, prospective studies are needed in the future.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>28502970</pmid><doi>10.1159/000476073</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cerebrovascular diseases (Basel, Switzerland), 2017-08, Vol.44 (1-2), p.75-82 |
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| subjects | Adult Aged Aneurysm Anopheles Cerebral aneurysm Cerebral Angiography - methods Diagnostic imaging Female Humans Intracranial Aneurysm - diagnostic imaging Intracranial Aneurysm - epidemiology Kidney diseases Magnetic Resonance Angiography Male Medical research Middle Aged Odds Ratio Patient Selection Polycystic kidney disease Polycystic Kidney, Autosomal Dominant - diagnosis Polycystic Kidney, Autosomal Dominant - epidemiology Predictive Value of Tests Prevalence Prognosis Review Risk Assessment Risk Factors Stroke Time Factors |
| title | Is Regular Screening for Intracranial Aneurysm Necessary in Patients with Autosomal Dominant Polycystic Kidney Disease? A Systematic Review and Meta-analysis |
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