Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor [alpha] to gp130 expression: fusing experimental insights and dynamic modelling

Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalling is initiated by binding of IL-6 to the IL-6 receptor [alpha] and subsequent binding to t...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell communication and signaling 2019-05, Vol.17 (1)
Hauptverfasser:	Reeh, Heike, Rudolph, Nadine, Billing, Ulrike, Christen, Henrike, Streif, Stefan, Bullinger, Eric, Schliemann-Bullinger, Monica, Findeisen, Rolf, Schaper, Fred, Huber, Heinrich J, Dittrich, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Cellular signal transduction Computer simulation Cytokines Inflammation Interleukins Molecular biology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!