Loss of NF-?B p50 function synergistically augments microglial priming in the middle-aged brain

Background While NF-?B p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-?B p50 in aging-associated microglial pro-inflammatory priming is poorly understood. Methods Male NF-?B p50.sup.+/+ and NF-?B p50.sup.-...

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Veröffentlicht in:	Journal of neuroinflammation 2019-03, Vol.16 (1)
Hauptverfasser:	Taetzsch, Thomas, Benusa, Savannah, Levesque, Shannon, Mumaw, Christen L, Block, Michelle L
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic aspects Health aspects Inflammation Microglia Middle age Physiological aspects Transcription factors
Online-Zugang:	Volltext
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