Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-[alpha]/p300-mediated acetylation of p53

Metabolic reprogramming is a typical feature of cancer cells aimed at sustaining high-energetic demand and proliferation rate. Here, we report clear-cut evidence for decreased expression of the adipose triglyceride lipase (ATGL), the first and rate-limiting enzyme of triglyceride hydrolysis, in both...

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Veröffentlicht in:	Oncogene 2019-03, Vol.38 (11), p.1860
Hauptverfasser:	Di Leo, Luca, Vegliante, Rolando, Ciccarone, Fabio, Salvatori, Illari, Scimeca, Manuel, Bonanno, Elena, Sagnotta, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Cancer Cancer cells Carcinoma Care and treatment Enzymes Fatty acids Gene expression Genetic aspects Glucose Glucose metabolism Glycolytic enzymes Hepatocellular carcinoma Hydrolysis Lipase Liver diseases Sorafenib Triglycerides Tumor proteins Tumors
Online-Zugang:	Volltext
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