Metformin sensitizes hypoxia-induced geftinib treatment resistance of HNSCC via cell cycle regulation and EMT reversal

Objectives: The objectives of this study were to explore the mechanisms of metformin sensitization to hypoxia-induced geftinib treatment in resistant head and neck squamous cell carcinoma (HNSCC) and evaluate the effects of this combined treatment strategy. Methods: The effects of geftinib treatment...

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Veröffentlicht in:	Cancer management and research 2018-01, Vol.10, p.5785
Hauptverfasser:	Yin, Xiteng, Wei, Zheng, Song, Chuanhui, Tang, Chuanchao, Xu, Wenguang, Wang, Yufeng, Xie, Junqi, Lin, Zitong, Han, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Anoxia Cancer Carcinoma Cell cycle Combination drug therapy Diabetes therapy Dosage and administration Drug therapy EDTA Gefitinib Head and neck cancer Health aspects Hypoglycemic agents Metformin Squamous cell carcinoma Stem cells Tumors
Online-Zugang:	Volltext
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