EGF-induced nuclear localization of SHCBP1 activates [beta]-catenin signaling and promotes cancer progression

Aberrant activation of EGFR represents a common event in non-small cell lung carcinoma (NSCLC) and activates various downstream signaling pathways. While EGFR activation of [beta]-catenin signaling was previously reported, the mediating mechanism remains unclear. Our current study found that EGFR ac...

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Veröffentlicht in:	Oncogene 2019-01, Vol.38 (2), p.747
Hauptverfasser:	Liu, Lei, Yang, Yi, Liu, Shihua, Tao, Tianyu, Cai, Junchao, Wu, Jueheng, Guan, Hongyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Carcinoma Care and treatment Development and progression Epidermal growth factor receptors Epidermal growth factors Gene expression Genetic aspects Health aspects Lung cancer Mediation Medical research Medical schools Non-small cell lung cancer Tumor proteins Tumors
Online-Zugang:	Volltext
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