Elevated cellular cholesterol in Familial Alzheimer's presenilin 1 mutation is associated with lipid raft localization of [beta]-amyloid precursor protein

Familial Alzheimer's disease (FAD)-associated presenilin 1 (PS1) serves as a catalytic subunit of [gamma]-secretase complex, which mediates the proteolytic liberation of [beta]-amyloid (A[beta]) from [beta]-amyloid precursor protein (APP). In addition to its proteolytic role, PS1 is involved in...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0210535
Hauptverfasser:	Cho, Yoon Young, Kwon, Oh-Hoon, Park, Myoung Kyu, Kim, Tae-Wan, Chung, Sungkwon
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Care and treatment Genetic aspects Lipids Risk factors
Online-Zugang:	Volltext
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