Role of mGlu2 in the 5-HT.sub.2A receptor-dependent antipsychotic activity of clozapine in mice

Background Serotonin 5-HT.sub.2A and metabotropic glutamate 2 (mGlu2) are neurotransmitter G protein-coupled receptors (GPCRs) involved in the signaling mechanisms underlying psychosis and schizophrenia treatment. Previous findings in mGlu2 knockout (KO) mice suggested that mGlu2 is necessary for he...

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Veröffentlicht in:	Psychopharmacology 2018-11, Vol.235 (11), p.3149
Hauptverfasser:	Hideshima, Kelsey S, Hojati, Ashkhan, Saunders, Justin M, On, Doan M, de la Fuente Revenga, Mario, Shin, Jong M, Sánchez-González, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Cellular signal transduction Clozapine Dosage and administration Health aspects Schizophrenia
Online-Zugang:	Volltext
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