Alcohol enhances type 1 interferon-[alpha] production and mortality in young mice infected with Mycobacterium tuberculosis

In the current study, we used a mouse model and human blood samples to determine the effects of chronic alcohol consumption on immune responses during Mycobacterium tuberculosis (Mtb) infection. Alcohol increased the mortality of young mice but not old mice with Mtb infection. CD11b+Ly6G+ cells are...

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Veröffentlicht in:	PLoS pathogens 2018-08, Vol.14 (8)
Hauptverfasser:	Tripathi, Deepak, Welch, Elwyn, Cheekatla, Satyanarayana Swamy, Radhakrishnan, Rajesh Kumar, Venkatasubramanian, Sambasivan, Paidipally, Padmaja, Van, Abhinav, Samten, Buka, Devalraju, Kamakshi P, Neela, Venkata Sanjeev Kumar, Valluri, Vijaya Lakshmi, Mason, Carol, Nelson, Steve, Vankayalapati, Ramakrishna
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Development and progression Dosage and administration Health aspects Interferon Laboratory rats Mycobacterium infections Risk factors Tuberculosis
Online-Zugang:	Volltext
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