Influenza infection directly alters innate IL-23 and IL-12p70 and subsequent IL-17A and IFN-[gamma] responses to pneumococcus in vitro in human monocytes

It is well accepted that influenza A virus predisposes individuals to often more severe superinfections with Streptococcus pneumonia. However, the mechanisms that lead to this synergy are not clearly understood. Recent data suggests that competent Th17 immunity is crucial to clearance and protection...

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Veröffentlicht in:	PloS one 2018-09, Vol.13 (9), p.e0203521
Hauptverfasser:	Loughran, Sinead T, Power, Patrick A, Maguire, Paula T, McQuaid, Samantha L, Buchanan, Paul J, Jonsdottir, Ingileif, Newman, Robert W, Harvey, Ruth, Johnson, Patricia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic aspects Health aspects Influenza viruses Interleukins Monocytes Physiological aspects
Online-Zugang:	Volltext
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