Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Glil signaling pathway

Fatty acid synthase (FASN), the main enzyme involved in de novo lipogenesis, is overexpressed in several types of tumor tissues. In addition, it is associated with tumor cell proliferation, metastasis, epithelial-mesenchymal transition (EMT) and a poor prognosis. However, the precise functions and i...

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Veröffentlicht in:	Oncology letters 2018-07, Vol.16 (1), p.594
Hauptverfasser:	Sun, Liang, Yao, Yizhou, Pan, Guofeng, Zhan, Shenghua, Shi, Weiqiang, Lu, Ting, Yuan, Jinfeng, Tian, Kangjun, Jiang, Linhua, Song, Shiduo, Zhu, Xinguo, He, Songbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Cellular signal transduction Development and progression Genetic aspects Health aspects Stomach cancer Transferases
Online-Zugang:	Volltext
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