A comparison between intravenous metoprolol and labetalol in prevention of cardiovascular stress response to laryngoscopy and intubation
Introduction: A prospective, randomized, double blind, clinical study was designed to compare intravenous metoprolol 30 [micro]g/l
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| Veröffentlicht in: | Anaesthesia, pain & intensive care pain & intensive care, 2018-04, Vol.22 (2), p.180 |
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| creator | Swami, Nishee R Badhe, Vaishalee K Deshpande, Vaishali V Badhe, Vaijayanti K Vinayak, Shidhaye Ramchandra |
| description | Introduction: A prospective, randomized, double blind, clinical study was designed to compare intravenous metoprolol 30 [micro]g/l |
| format | Article |
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Methodology: Sixty ASA grade I patients of either sex, comprising age group of 25-50 years, undergoing elective spine surgeries under general anesthesia were randomly distributed in two equal groups. Inj metoprolol hydrochloride 30 [micro]g/kg in Group M and inj labetalol 0.2 mg/kg in Group L respectively were given intravenously 5 min prior to induction. Heart rate, systolic, diastolic and MBP recorded at different time intervals before and after intubation. Results: Significant rise noted in heart rate, systolic, diastolic and MBP immediately after intubation in both groups though less in Group L that remained up to 2 min; returned to baseline between 2 to 5 min and became significantly lower than baseline at 5 min and onwards. Conclusion: Labetalol is superior to metoprolol in attenuating the cardiovascular stress response to laryngoscopy and intubation. Key words: Labetalol, Metoprolol, Presser response, Laryngoscopy, Tracheal intubation</description><identifier>ISSN: 1607-8322</identifier><language>eng</language><publisher>Sage Publications Ltd. (UK)</publisher><subject>Cardiovascular diseases ; Dosage and administration ; Drug therapy ; Intubation ; Labetalol ; Laryngoscopy ; Metoprolol ; Prevention</subject><ispartof>Anaesthesia, pain & intensive care, 2018-04, Vol.22 (2), p.180</ispartof><rights>COPYRIGHT 2018 Sage Publications Ltd. (UK)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Swami, Nishee R</creatorcontrib><creatorcontrib>Badhe, Vaishalee K</creatorcontrib><creatorcontrib>Deshpande, Vaishali V</creatorcontrib><creatorcontrib>Badhe, Vaijayanti K</creatorcontrib><creatorcontrib>Vinayak, Shidhaye Ramchandra</creatorcontrib><title>A comparison between intravenous metoprolol and labetalol in prevention of cardiovascular stress response to laryngoscopy and intubation</title><title>Anaesthesia, pain & intensive care</title><description>Introduction: A prospective, randomized, double blind, clinical study was designed to compare intravenous metoprolol 30 [micro]g/l<g versus intravenous labetalol 0.2 mg/kg single dose given 5 min prior to intubation in for prevention of cardiovascular stress response to laryngoscopy and intubation in patients undergoing spine surgeries under general anesthesia. Methodology: Sixty ASA grade I patients of either sex, comprising age group of 25-50 years, undergoing elective spine surgeries under general anesthesia were randomly distributed in two equal groups. Inj metoprolol hydrochloride 30 [micro]g/kg in Group M and inj labetalol 0.2 mg/kg in Group L respectively were given intravenously 5 min prior to induction. Heart rate, systolic, diastolic and MBP recorded at different time intervals before and after intubation. Results: Significant rise noted in heart rate, systolic, diastolic and MBP immediately after intubation in both groups though less in Group L that remained up to 2 min; returned to baseline between 2 to 5 min and became significantly lower than baseline at 5 min and onwards. Conclusion: Labetalol is superior to metoprolol in attenuating the cardiovascular stress response to laryngoscopy and intubation. Key words: Labetalol, Metoprolol, Presser response, Laryngoscopy, Tracheal intubation</description><subject>Cardiovascular diseases</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Intubation</subject><subject>Labetalol</subject><subject>Laryngoscopy</subject><subject>Metoprolol</subject><subject>Prevention</subject><issn>1607-8322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj89qwzAMxnPYYKXrOxh2zkisOHaOpewfFHbZzsVx5OKRWMF2O_oGe-y52w471AIJSb_vE74qFnVbyVIB5zfFKsaPKj_RqFqIRfG1ZoamWQcXybMe0yeiZ86noI_o6RDZhInmQCONTPuBjTpD-tw5z-aAmUouS8kyo8Pg6KijOYw6sJgCxshymslHZImyOJz8nqKh-fTjlg8den02uC2urR4jrv7qsnh_fHjbPJfb16eXzXpb7jnnqYRKiUFLK7sejISaAzY9yM72ilvFQWLdASjeDK1thLUt76EVdYUttDyvYVnc_fru9Yg75y3lr5rJRbNbCwFSdEqcqfsLVI4BJ2fIo3V5_k_wDRzhcD8</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Swami, Nishee R</creator><creator>Badhe, Vaishalee K</creator><creator>Deshpande, Vaishali V</creator><creator>Badhe, Vaijayanti K</creator><creator>Vinayak, Shidhaye Ramchandra</creator><general>Sage Publications Ltd. (UK)</general><scope/></search><sort><creationdate>20180401</creationdate><title>A comparison between intravenous metoprolol and labetalol in prevention of cardiovascular stress response to laryngoscopy and intubation</title><author>Swami, Nishee R ; Badhe, Vaishalee K ; Deshpande, Vaishali V ; Badhe, Vaijayanti K ; Vinayak, Shidhaye Ramchandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g222t-3085da7f79b3c73123e4b379fb82f8237e1933824d6f45ff62b36510e63622373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cardiovascular diseases</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Intubation</topic><topic>Labetalol</topic><topic>Laryngoscopy</topic><topic>Metoprolol</topic><topic>Prevention</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swami, Nishee R</creatorcontrib><creatorcontrib>Badhe, Vaishalee K</creatorcontrib><creatorcontrib>Deshpande, Vaishali V</creatorcontrib><creatorcontrib>Badhe, Vaijayanti K</creatorcontrib><creatorcontrib>Vinayak, Shidhaye Ramchandra</creatorcontrib><jtitle>Anaesthesia, pain & intensive care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swami, Nishee R</au><au>Badhe, Vaishalee K</au><au>Deshpande, Vaishali V</au><au>Badhe, Vaijayanti K</au><au>Vinayak, Shidhaye Ramchandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison between intravenous metoprolol and labetalol in prevention of cardiovascular stress response to laryngoscopy and intubation</atitle><jtitle>Anaesthesia, pain & intensive care</jtitle><date>2018-04-01</date><risdate>2018</risdate><volume>22</volume><issue>2</issue><spage>180</spage><pages>180-</pages><issn>1607-8322</issn><abstract>Introduction: A prospective, randomized, double blind, clinical study was designed to compare intravenous metoprolol 30 [micro]g/l<g versus intravenous labetalol 0.2 mg/kg single dose given 5 min prior to intubation in for prevention of cardiovascular stress response to laryngoscopy and intubation in patients undergoing spine surgeries under general anesthesia. Methodology: Sixty ASA grade I patients of either sex, comprising age group of 25-50 years, undergoing elective spine surgeries under general anesthesia were randomly distributed in two equal groups. Inj metoprolol hydrochloride 30 [micro]g/kg in Group M and inj labetalol 0.2 mg/kg in Group L respectively were given intravenously 5 min prior to induction. Heart rate, systolic, diastolic and MBP recorded at different time intervals before and after intubation. Results: Significant rise noted in heart rate, systolic, diastolic and MBP immediately after intubation in both groups though less in Group L that remained up to 2 min; returned to baseline between 2 to 5 min and became significantly lower than baseline at 5 min and onwards. Conclusion: Labetalol is superior to metoprolol in attenuating the cardiovascular stress response to laryngoscopy and intubation. Key words: Labetalol, Metoprolol, Presser response, Laryngoscopy, Tracheal intubation</abstract><pub>Sage Publications Ltd. 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| ispartof | Anaesthesia, pain & intensive care, 2018-04, Vol.22 (2), p.180 |
| issn | 1607-8322 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Cardiovascular diseases Dosage and administration Drug therapy Intubation Labetalol Laryngoscopy Metoprolol Prevention |
| title | A comparison between intravenous metoprolol and labetalol in prevention of cardiovascular stress response to laryngoscopy and intubation |
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