Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-[kappa]B activation

Nuclear factor [kappa]B (NF-[kappa]B) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-[kappa]B and its upstream regulator I[kappa]B kinase (IKK) contributes to the pathogenesis of multiple inflamm...

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Veröffentlicht in:	PLoS biology 2018-06, Vol.16 (6)
Hauptverfasser:	Zhao, Jing, Zhang, Lei, Mu, Xiaodong, Doebelin, Christelle, Nguyen, William, Wallace, Callen, Reay, Daniel P, McGowan, Sara J, Corbo, Lana, Clemens, Paula R, Wilson, Gabriela Mustata, Watkins, Simon C, Solt, Laura A, Cameron, Michael D, Huard, Johnny, Niedernhofer, Laura J, Kamenecka, Theodore M, Robbins, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites (Biochemistry) Observations Physiological aspects Transcription factors
Online-Zugang:	Volltext
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