Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus/Plazma Aterojenik Indeks, Sistemik Lupus Eritematozusunda Subklinik Aterosklerozun Bagimsiz Bir Gostergedir
Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk...
Gespeichert in:
| Veröffentlicht in: | The Eurasian journal of medicine 2017-10, Vol.49 (3), p.193 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 193 |
| container_title | The Eurasian journal of medicine |
| container_volume | 49 |
| creator | Ugur Uslu, Ali Kucuk, Adem Icli, Abdullah Cure, Erkan Sakiz, Davut Arslan, Sevket Aydogan Baykara, Rabia |
| description | Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria. Furthermore, we selected age- and body mass index (BMI)-matched 56 female healthy individuals. PAI was measured as a logarithmic value of triglyceride to high-density cholesterol ratio. We used carotid intima media thickness (cIMT) as an inflammatory marker because of its widespread use. The lipid and other biochemical parameters of patient and control groups were examined. Results: The PAI and cIMT values of SLE patients were 0.04 [+ or -] 0.23 and 0.78 [+ or -] 0.18 mm, respectively. Besides, for the control group, the PAI value was -0.09 [+ or -] 0.20 and cIMT value was 0.50 [+ or -] 0.15 mm (p=0.002, p |
| doi_str_mv | 10.5l52/eurasianjmed.20l7.l7l43 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A541892083</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A541892083</galeid><sourcerecordid>A541892083</sourcerecordid><originalsourceid>FETCH-LOGICAL-g673-65243e9b30f3cf925a94e0e7c2c2db8fa3cdd1e88d0efee4fe09df443759b0a03</originalsourceid><addsrcrecordid>eNptkNFqwjAUhnuxwcT5DAvsdq2xSW17qeKcIGyg95ImJ11smkrTwuzL7lWWVhm7WALnHML_nQ_ieU8zHEQ6CqfQ1swqZk4liCDEOg50rCm580YzghM_iQl98CbWnrA7NCUknI-87w_NbMnQovmEusrBKI62RsAXUhYxM8xncMU0_aw4a6oaVRLt24xr5eJM32DLdV8dpwzaX2wDpVu2a8-tRev64jKlg21rp87ZDU6XPzllMWgK-4L2asCKX0w1A9W1tjWC9daitxZX2Ba9smsNWrJclVZ1aKlqtKncljoHoepH714ybWFy62Pv8Lo-rN783ftmu1rs_HweE38ehZRAmhEsCZdpGLGUAoaYhzwUWSIZ4ULMIEkEBglAJeBUSEpJHKUZZpiMvefr2pxpOCojq6ZmvFSWHxcRnSVpiBPiUsE_KXdF_1WVAanc-x_gB2PPm30</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus/Plazma Aterojenik Indeks, Sistemik Lupus Eritematozusunda Subklinik Aterosklerozun Bagimsiz Bir Gostergedir</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Ugur Uslu, Ali ; Kucuk, Adem ; Icli, Abdullah ; Cure, Erkan ; Sakiz, Davut ; Arslan, Sevket ; Aydogan Baykara, Rabia</creator><creatorcontrib>Ugur Uslu, Ali ; Kucuk, Adem ; Icli, Abdullah ; Cure, Erkan ; Sakiz, Davut ; Arslan, Sevket ; Aydogan Baykara, Rabia</creatorcontrib><description>Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria. Furthermore, we selected age- and body mass index (BMI)-matched 56 female healthy individuals. PAI was measured as a logarithmic value of triglyceride to high-density cholesterol ratio. We used carotid intima media thickness (cIMT) as an inflammatory marker because of its widespread use. The lipid and other biochemical parameters of patient and control groups were examined. Results: The PAI and cIMT values of SLE patients were 0.04 [+ or -] 0.23 and 0.78 [+ or -] 0.18 mm, respectively. Besides, for the control group, the PAI value was -0.09 [+ or -] 0.20 and cIMT value was 0.50 [+ or -] 0.15 mm (p=0.002, p<0.001; respectively). There was a strong correlation between cIMT and PAI (r=0.273, p=0.003). According to the multiple logistic regression analysis, we found that PAI value is an independent factor for cIMT in SLE patients (odds ratio: 2.6, 95 % confidence interval; 1.506-4.374; p=0.029). Conclusions: We determined that PAI can be used as an independent indicator for subclinical atherosclerosis in SLE patients. Keywords: Plasma atherogenic index, carotid intima-media thickness, systemic lupus erythematosus, atherosclerosis Amac: Sistemik lupus eritematozus (SLE), kronik inflamasyon ile karakterize bir hastaliktir Plazma aterojenik indeks (PAI), kardiyovaskuler hastalik ve kardiyak risk icin degerli bir belirtectir Bu calismanin amaci PAI'in SLE hastalarinda aterosklerozu ve kardiyak riski degerlendirmekteki rolu ve klinik kullanilabilirliligini arastirmaktir Gerec ve Yontem: Amerikan Romatoloji Koleji (1997) tani kriterlerine gore degerlendirilen 56 kadin SLE hastasi dahil edildi. Ayrica yas ve vucut kitle indeksi uyumlu 56 kadin saglikli kisi secildi. PAI, trigliserit'in yuksek yogunluklu kolesterole orani logartimik olcumudur Karotis intima medya kalinligi (KIMK) inflamatuvar belirtec olarak yaygin olarak kullanildigindan, bu isareti bu calismada kullandik. Hasta ve kontrol gruplarinin lipid ve diger biyokimyasal parametreleri incelendi. Bulgular: Hasta grubunda PAI 0, 04 [+ or -] 0, 23, KIMK 0, 78 [+ or -] 0,18 mm, kontrol grubunda PAI -0,09 [+ or -] 0,20, KIMK 0, 50 [+ or -] 0, 15 mm oldugu tespit edildi. Hasta grubunda PAI ve KIMK'in kontrol grubuna kiyasla yuksek oldugu goruldu (sirasiyla p=0, 002, p<0, 001). SLE hastalari icerisine KIMK ile PAI arasinda pozitif korelasyon oldugu goruldu (r=0, 273, p=0, 003). Multipl logistik regresyon analize gore PAI, KIMK icin bagimsiz risk faktoru olarak degerlendirildi (Olasilik orani: 2, 6, Guven araligi %95 1, 506-4, 374, p=0, 029). Sonuc: Bu calisma bize PAI'n?n SLE hastalarinda subklinik aterosklerozun degerlendirilmesinde kullanilabilecek bagimsiz bir belirtec olabilecegini dusundurdu. Anahtar Kelimeler: Plazma aterojenik indeks, karotis intima medya kalinligi, Sistemik lupus eritematozus, aterosklerozis</description><identifier>ISSN: 1308-8734</identifier><identifier>DOI: 10.5l52/eurasianjmed.20l7.l7l43</identifier><language>eng</language><publisher>AVES</publisher><subject>Atherosclerosis ; Cardiovascular diseases ; Development and progression ; Risk factors ; Systemic lupus erythematosus</subject><ispartof>The Eurasian journal of medicine, 2017-10, Vol.49 (3), p.193</ispartof><rights>COPYRIGHT 2017 AVES</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids></links><search><creatorcontrib>Ugur Uslu, Ali</creatorcontrib><creatorcontrib>Kucuk, Adem</creatorcontrib><creatorcontrib>Icli, Abdullah</creatorcontrib><creatorcontrib>Cure, Erkan</creatorcontrib><creatorcontrib>Sakiz, Davut</creatorcontrib><creatorcontrib>Arslan, Sevket</creatorcontrib><creatorcontrib>Aydogan Baykara, Rabia</creatorcontrib><title>Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus/Plazma Aterojenik Indeks, Sistemik Lupus Eritematozusunda Subklinik Aterosklerozun Bagimsiz Bir Gostergedir</title><title>The Eurasian journal of medicine</title><description>Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria. Furthermore, we selected age- and body mass index (BMI)-matched 56 female healthy individuals. PAI was measured as a logarithmic value of triglyceride to high-density cholesterol ratio. We used carotid intima media thickness (cIMT) as an inflammatory marker because of its widespread use. The lipid and other biochemical parameters of patient and control groups were examined. Results: The PAI and cIMT values of SLE patients were 0.04 [+ or -] 0.23 and 0.78 [+ or -] 0.18 mm, respectively. Besides, for the control group, the PAI value was -0.09 [+ or -] 0.20 and cIMT value was 0.50 [+ or -] 0.15 mm (p=0.002, p<0.001; respectively). There was a strong correlation between cIMT and PAI (r=0.273, p=0.003). According to the multiple logistic regression analysis, we found that PAI value is an independent factor for cIMT in SLE patients (odds ratio: 2.6, 95 % confidence interval; 1.506-4.374; p=0.029). Conclusions: We determined that PAI can be used as an independent indicator for subclinical atherosclerosis in SLE patients. Keywords: Plasma atherogenic index, carotid intima-media thickness, systemic lupus erythematosus, atherosclerosis Amac: Sistemik lupus eritematozus (SLE), kronik inflamasyon ile karakterize bir hastaliktir Plazma aterojenik indeks (PAI), kardiyovaskuler hastalik ve kardiyak risk icin degerli bir belirtectir Bu calismanin amaci PAI'in SLE hastalarinda aterosklerozu ve kardiyak riski degerlendirmekteki rolu ve klinik kullanilabilirliligini arastirmaktir Gerec ve Yontem: Amerikan Romatoloji Koleji (1997) tani kriterlerine gore degerlendirilen 56 kadin SLE hastasi dahil edildi. Ayrica yas ve vucut kitle indeksi uyumlu 56 kadin saglikli kisi secildi. PAI, trigliserit'in yuksek yogunluklu kolesterole orani logartimik olcumudur Karotis intima medya kalinligi (KIMK) inflamatuvar belirtec olarak yaygin olarak kullanildigindan, bu isareti bu calismada kullandik. Hasta ve kontrol gruplarinin lipid ve diger biyokimyasal parametreleri incelendi. Bulgular: Hasta grubunda PAI 0, 04 [+ or -] 0, 23, KIMK 0, 78 [+ or -] 0,18 mm, kontrol grubunda PAI -0,09 [+ or -] 0,20, KIMK 0, 50 [+ or -] 0, 15 mm oldugu tespit edildi. Hasta grubunda PAI ve KIMK'in kontrol grubuna kiyasla yuksek oldugu goruldu (sirasiyla p=0, 002, p<0, 001). SLE hastalari icerisine KIMK ile PAI arasinda pozitif korelasyon oldugu goruldu (r=0, 273, p=0, 003). Multipl logistik regresyon analize gore PAI, KIMK icin bagimsiz risk faktoru olarak degerlendirildi (Olasilik orani: 2, 6, Guven araligi %95 1, 506-4, 374, p=0, 029). Sonuc: Bu calisma bize PAI'n?n SLE hastalarinda subklinik aterosklerozun degerlendirilmesinde kullanilabilecek bagimsiz bir belirtec olabilecegini dusundurdu. Anahtar Kelimeler: Plazma aterojenik indeks, karotis intima medya kalinligi, Sistemik lupus eritematozus, aterosklerozis</description><subject>Atherosclerosis</subject><subject>Cardiovascular diseases</subject><subject>Development and progression</subject><subject>Risk factors</subject><subject>Systemic lupus erythematosus</subject><issn>1308-8734</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptkNFqwjAUhnuxwcT5DAvsdq2xSW17qeKcIGyg95ImJ11smkrTwuzL7lWWVhm7WALnHML_nQ_ieU8zHEQ6CqfQ1swqZk4liCDEOg50rCm580YzghM_iQl98CbWnrA7NCUknI-87w_NbMnQovmEusrBKI62RsAXUhYxM8xncMU0_aw4a6oaVRLt24xr5eJM32DLdV8dpwzaX2wDpVu2a8-tRev64jKlg21rp87ZDU6XPzllMWgK-4L2asCKX0w1A9W1tjWC9daitxZX2Ba9smsNWrJclVZ1aKlqtKncljoHoepH714ybWFy62Pv8Lo-rN783ftmu1rs_HweE38ehZRAmhEsCZdpGLGUAoaYhzwUWSIZ4ULMIEkEBglAJeBUSEpJHKUZZpiMvefr2pxpOCojq6ZmvFSWHxcRnSVpiBPiUsE_KXdF_1WVAanc-x_gB2PPm30</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Ugur Uslu, Ali</creator><creator>Kucuk, Adem</creator><creator>Icli, Abdullah</creator><creator>Cure, Erkan</creator><creator>Sakiz, Davut</creator><creator>Arslan, Sevket</creator><creator>Aydogan Baykara, Rabia</creator><general>AVES</general><scope/></search><sort><creationdate>20171001</creationdate><title>Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus/Plazma Aterojenik Indeks, Sistemik Lupus Eritematozusunda Subklinik Aterosklerozun Bagimsiz Bir Gostergedir</title><author>Ugur Uslu, Ali ; Kucuk, Adem ; Icli, Abdullah ; Cure, Erkan ; Sakiz, Davut ; Arslan, Sevket ; Aydogan Baykara, Rabia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g673-65243e9b30f3cf925a94e0e7c2c2db8fa3cdd1e88d0efee4fe09df443759b0a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Atherosclerosis</topic><topic>Cardiovascular diseases</topic><topic>Development and progression</topic><topic>Risk factors</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ugur Uslu, Ali</creatorcontrib><creatorcontrib>Kucuk, Adem</creatorcontrib><creatorcontrib>Icli, Abdullah</creatorcontrib><creatorcontrib>Cure, Erkan</creatorcontrib><creatorcontrib>Sakiz, Davut</creatorcontrib><creatorcontrib>Arslan, Sevket</creatorcontrib><creatorcontrib>Aydogan Baykara, Rabia</creatorcontrib><jtitle>The Eurasian journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ugur Uslu, Ali</au><au>Kucuk, Adem</au><au>Icli, Abdullah</au><au>Cure, Erkan</au><au>Sakiz, Davut</au><au>Arslan, Sevket</au><au>Aydogan Baykara, Rabia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus/Plazma Aterojenik Indeks, Sistemik Lupus Eritematozusunda Subklinik Aterosklerozun Bagimsiz Bir Gostergedir</atitle><jtitle>The Eurasian journal of medicine</jtitle><date>2017-10-01</date><risdate>2017</risdate><volume>49</volume><issue>3</issue><spage>193</spage><pages>193-</pages><issn>1308-8734</issn><abstract>Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria. Furthermore, we selected age- and body mass index (BMI)-matched 56 female healthy individuals. PAI was measured as a logarithmic value of triglyceride to high-density cholesterol ratio. We used carotid intima media thickness (cIMT) as an inflammatory marker because of its widespread use. The lipid and other biochemical parameters of patient and control groups were examined. Results: The PAI and cIMT values of SLE patients were 0.04 [+ or -] 0.23 and 0.78 [+ or -] 0.18 mm, respectively. Besides, for the control group, the PAI value was -0.09 [+ or -] 0.20 and cIMT value was 0.50 [+ or -] 0.15 mm (p=0.002, p<0.001; respectively). There was a strong correlation between cIMT and PAI (r=0.273, p=0.003). According to the multiple logistic regression analysis, we found that PAI value is an independent factor for cIMT in SLE patients (odds ratio: 2.6, 95 % confidence interval; 1.506-4.374; p=0.029). Conclusions: We determined that PAI can be used as an independent indicator for subclinical atherosclerosis in SLE patients. Keywords: Plasma atherogenic index, carotid intima-media thickness, systemic lupus erythematosus, atherosclerosis Amac: Sistemik lupus eritematozus (SLE), kronik inflamasyon ile karakterize bir hastaliktir Plazma aterojenik indeks (PAI), kardiyovaskuler hastalik ve kardiyak risk icin degerli bir belirtectir Bu calismanin amaci PAI'in SLE hastalarinda aterosklerozu ve kardiyak riski degerlendirmekteki rolu ve klinik kullanilabilirliligini arastirmaktir Gerec ve Yontem: Amerikan Romatoloji Koleji (1997) tani kriterlerine gore degerlendirilen 56 kadin SLE hastasi dahil edildi. Ayrica yas ve vucut kitle indeksi uyumlu 56 kadin saglikli kisi secildi. PAI, trigliserit'in yuksek yogunluklu kolesterole orani logartimik olcumudur Karotis intima medya kalinligi (KIMK) inflamatuvar belirtec olarak yaygin olarak kullanildigindan, bu isareti bu calismada kullandik. Hasta ve kontrol gruplarinin lipid ve diger biyokimyasal parametreleri incelendi. Bulgular: Hasta grubunda PAI 0, 04 [+ or -] 0, 23, KIMK 0, 78 [+ or -] 0,18 mm, kontrol grubunda PAI -0,09 [+ or -] 0,20, KIMK 0, 50 [+ or -] 0, 15 mm oldugu tespit edildi. Hasta grubunda PAI ve KIMK'in kontrol grubuna kiyasla yuksek oldugu goruldu (sirasiyla p=0, 002, p<0, 001). SLE hastalari icerisine KIMK ile PAI arasinda pozitif korelasyon oldugu goruldu (r=0, 273, p=0, 003). Multipl logistik regresyon analize gore PAI, KIMK icin bagimsiz risk faktoru olarak degerlendirildi (Olasilik orani: 2, 6, Guven araligi %95 1, 506-4, 374, p=0, 029). Sonuc: Bu calisma bize PAI'n?n SLE hastalarinda subklinik aterosklerozun degerlendirilmesinde kullanilabilecek bagimsiz bir belirtec olabilecegini dusundurdu. Anahtar Kelimeler: Plazma aterojenik indeks, karotis intima medya kalinligi, Sistemik lupus eritematozus, aterosklerozis</abstract><pub>AVES</pub><doi>10.5l52/eurasianjmed.20l7.l7l43</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1308-8734 |
| ispartof | The Eurasian journal of medicine, 2017-10, Vol.49 (3), p.193 |
| issn | 1308-8734 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A541892083 |
| source | DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Atherosclerosis Cardiovascular diseases Development and progression Risk factors Systemic lupus erythematosus |
| title | Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus/Plazma Aterojenik Indeks, Sistemik Lupus Eritematozusunda Subklinik Aterosklerozun Bagimsiz Bir Gostergedir |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T07%3A35%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20Atherogenic%20Index%20is%20an%20Independent%20Indicator%20of%20Subclinical%20Atherosclerosis%20in%20Systemic%20Lupus%20Erythematosus/Plazma%20Aterojenik%20Indeks,%20Sistemik%20Lupus%20Eritematozusunda%20Subklinik%20Aterosklerozun%20Bagimsiz%20Bir%20Gostergedir&rft.jtitle=The%20Eurasian%20journal%20of%20medicine&rft.au=Ugur%20Uslu,%20Ali&rft.date=2017-10-01&rft.volume=49&rft.issue=3&rft.spage=193&rft.pages=193-&rft.issn=1308-8734&rft_id=info:doi/10.5l52/eurasianjmed.20l7.l7l43&rft_dat=%3Cgale%3EA541892083%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A541892083&rfr_iscdi=true |