Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia/Fibromiyalji Hastalarinda D Vitamini Tedavisinin Yasam Kalitesi Uzerinde Etkisi

Objective: The role of vitamin D in the etiopathogenesis of fibromyalgia and non-specific musculoskeletal pain is controversial. In our study, we aimed to investigate the effect of vitamin D therapy on quality of life in patients with fibromyalgia. Materials and Methods: Seventy patients diagnosed with fibromyalgia and 65 age- and sex-matched controls were included in the study. Patients were grouped as deficient (30 ng/mL) according to the levels of vitamin D. Vitamin D replacement was performed for patients with deficiencies and inadequacies. Before and after vitamin D therapy, patients filled in the assessment tools, fibromyalgia impact questionnaire (FIQ), Arizona sexual experience scale (ASEX), Beck depression inventory (BDI), visual analog scale (VAS), and short form-36 (SF-36). Results: Vitamin D deficiencies and inadequacies were observed in 60% of the patients (n=42). Among patients with low and normal levels of vitamin D, no statistically significant difference was observed in their values. In scales examined after vitamin D replacement therapy, statistically significant differences were observed in the FIQ, BDI, VAS, and SF-36 compared with pre-treatment. Conclusion: Vitamin D deficiency seems to be linked to the pathogenesis of fibromyalgia. Vitamin D supplementation may improve the quality of life in patients with fibromyalgia. Keywords: Depression, fibromyalgia, quality of life, vitamin D, widespread pain Amac: D vitamininin fibromiyalji ve nonspesifik kas-iskelet sistemi agrilarinin etyopatogenezindeki rolu tartismalidir. Calismamizda fibromiyalji hastalarinda D vitamini tedavisinin yasam kalitesi uzerine etkisini arastirmayi amacladik. Gerec ve Yontem: Calismaya fibromiyalji tanisi konulan 70 hasta ve yas-cinsiyet olarak benzer 65 kisi kontrol grubu olarak dahil edildi. D vitamini duzeylerine gore hastalar, eksiklik ( 30 ng/mL) olarak gruplandirildi. Eksiklik ve yetersizlik saptanan hastalar icin D vitamini replasmani yapildi. D vitamini tedavisinden once ve sonra, hastalar yasam kalitesi formlari olan fibromiyalji etkilenme anketi (FEA), Arizona cinsel yasantilar olcegi (ACYO), Beck depresyon olcegi (BDO), Vizuel Analog skala (VAS) and Kisa form-36 (KF-36) ile degerlendirildi. Bulgular: D vitamini eksikligi ve yetersizligi hastalarin % 60'inda (n=42) gozlendi. D vitamini dusuk ve normal hastalar arasinda yasam kalitesi acisindan istati