Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and [beta]1-integrin signaling pathway in tumor cells

Introduction Acquired tamoxifen resistance remains the major obstacle to breast cancer endocrine therapy. [beta]1-integrin was identified as one of the target genes of G protein-coupled estrogen receptor (GPER), a novel estrogen receptor recognized as an initiator of tamoxifen resistance. Here, we i...

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Veröffentlicht in:	Breast cancer research : BCR 2015-05, Vol.17
Hauptverfasser:	Yuan, Jie, Liu, Manran, Yang, Li, Tu, Gang, Zhu, Qing, Chen, Maoshan, Cheng, Hong, Luo, Haojun, Fu, Weijie, Li, Zhenhua, Yang, Guanglun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Breast cancer Cancer Care and treatment Drug therapy G proteins Genetic aspects Metastasis
Online-Zugang:	Volltext
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