RNAi screening of subtracted transcriptomes reveals tumor suppression by taurine-activated GABA.sub.A receptors involved in volume regulation

To identify coding and non-coding suppressor genes of anchorage-independent proliferation by efficient loss-of-function screening, we have developed a method for enzymatic production of low complexity shRNA libraries from subtracted transcriptomes. We produced and screened two LEGO (Low-complexity b...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0196979
Hauptverfasser:	Wielders, Camiel L. C, van Nierop, Pim, Vormer, Tinke L, Foijer, Floris, Verheij, Joanne, Lodder, Johannes C, Andersen, Jesper B, Mansvelder, Huibert D, te Riele, Hein
Format:	Artikel
Sprache:	eng
Schlagworte:	Fibroblasts Genetic aspects RNA Transcription factors Tumors
Online-Zugang:	Volltext
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