Synthesis and Antiaggregant Activity of 2-[3-Methyl-1-Ethylxanthinyl-8-Thio]Acetic Acid Salts Containing a Thietane Ring
Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acids containing a thietane ring with yields of 76 – 93%. Interaction of these acids with bases (sodium hydro...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2018-04, Vol.52 (1), p.52-56 |
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| container_title | Pharmaceutical chemistry journal |
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| creator | Khaliullin, F. A. Shabalina, Yu. V. Samorodov, A. V. Kamilov, F. Kh Timirkhanova, G. A. Murataev, D. Z. |
| description | Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acids containing a thietane ring with yields of 76 – 93%. Interaction of these acids with bases (sodium hydroxide, morpholine, hexamethyleneimine) produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acid salts containing a thietane ring, with yields of 44 – 96%. The structures of these compounds were confirmed by IR and NMR spectroscopy data. The compounds synthesized here had potentially high antiaggregatory activity. |
| doi_str_mv | 10.1007/s11094-018-1764-y |
| format | Article |
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The structures of these compounds were confirmed by IR and NMR spectroscopy data. The compounds synthesized here had potentially high antiaggregatory activity.</description><subject>Acetic acid</subject><subject>Hydroxides</subject><subject>Medicine</subject><subject>Nuclear magnetic resonance spectroscopy</subject><subject>Organic acids</subject><subject>Organic Chemistry</subject><subject>Pentoxifylline</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Xanthine</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kU1LxDAQhoMouK7-AG8Bz9FM03TbY1n8ghVBVxBEQkwn3Sy7qTRR7L83S70IInMYZniegeEl5BT4OXA-uwgAvMoZh5LBrMjZsEcmIGeCVVzAPplwXgEDyZ8PyVEIa86TJbIJ-XocfFxhcIFq39DaR6fbtsdW-0hrE92niwPtLM3Yi2B3GFfDhgG73PWvxKycT4uSLVeue60NRmeS5hr6qDcx0Hnno3be-ZZqmhiM2iN9SPMxObB6E_Dkp0_J09Xlcn7DFvfXt_N6wYyQMjJtTSky2WQgAApuK5PlxhRWCEBuG4OiMGXeSGhQvgmBRsuswCbTBZaVRS2m5Gy82-oNKudtF3ttti4YVUtR5DmAFIk6_4NK1eDWmc6jdWn_S4BRMH0XQo9Wvfduq_tBAVe7RNSYiEqJqF0iakhONjohsb7FXq27j96n7_-RvgGIcY7m</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Khaliullin, F. 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Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Antiaggregant Activity of 2-[3-Methyl-1-Ethylxanthinyl-8-Thio]Acetic Acid Salts Containing a Thietane Ring</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2018-04-01</date><risdate>2018</risdate><volume>52</volume><issue>1</issue><spage>52</spage><epage>56</epage><pages>52-56</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acids containing a thietane ring with yields of 76 – 93%. Interaction of these acids with bases (sodium hydroxide, morpholine, hexamethyleneimine) produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acid salts containing a thietane ring, with yields of 44 – 96%. The structures of these compounds were confirmed by IR and NMR spectroscopy data. The compounds synthesized here had potentially high antiaggregatory activity.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-018-1764-y</doi><tpages>5</tpages></addata></record> |
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| subjects | Acetic acid Hydroxides Medicine Nuclear magnetic resonance spectroscopy Organic acids Organic Chemistry Pentoxifylline Pharmacology/Toxicology Pharmacy Xanthine |
| title | Synthesis and Antiaggregant Activity of 2-[3-Methyl-1-Ethylxanthinyl-8-Thio]Acetic Acid Salts Containing a Thietane Ring |
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