Gestational Diabetes Induces Pancreatic Beta-Cells Apoptosis in Adult Rat Offspring/Diabetes Gestacional Induce Apoptosis de Celulas Beta del Pancreas en Crias de Ratas Adultas
Several studies indicated that pancreatic [beta]-cells death occurs in both type 1 and type 2 diabetes. This experimental study was designed to determine the effect of gestational diabetes on the [beta]-cellss in 16-week-old rat offspring. By this aim, adult Wistar rats aged 10-12 weeks were randoml...
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| Veröffentlicht in: | International journal of morphology 2017-03, Vol.35 (1), p.16 |
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| container_title | International journal of morphology |
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| creator | Nazari, Zahra Nabiuni, Mohammad Ghaffari, Soraya Saeidi, Mohsen Shahriyari, Alireza Golalipour, Mohammad Jafar |
| description | Several studies indicated that pancreatic [beta]-cells death occurs in both type 1 and type 2 diabetes. This experimental study was designed to determine the effect of gestational diabetes on the [beta]-cellss in 16-week-old rat offspring. By this aim, adult Wistar rats aged 10-12 weeks were randomly allocated in control and diabetic groups. The diabetic group received 40 mg/kg/body weight of streptozotocin (STZ) on day zero of gestation. After delivery, diabetic offspring of GDM mothers and controls at the age of 16 weeks were sacrificed and pancreases harvested and fixed. The number of [beta]-cellss and were counted by Gomori's method staining. Also, apoptosis in pancreas tissue of diabetic and control offspring was detected by TUNEL assay. Results showed a significant reduction in [beta]-cells number in offspring of GDM (p |
| format | Article |
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This experimental study was designed to determine the effect of gestational diabetes on the [beta]-cellss in 16-week-old rat offspring. By this aim, adult Wistar rats aged 10-12 weeks were randomly allocated in control and diabetic groups. The diabetic group received 40 mg/kg/body weight of streptozotocin (STZ) on day zero of gestation. After delivery, diabetic offspring of GDM mothers and controls at the age of 16 weeks were sacrificed and pancreases harvested and fixed. The number of [beta]-cellss and were counted by Gomori's method staining. Also, apoptosis in pancreas tissue of diabetic and control offspring was detected by TUNEL assay. Results showed a significant reduction in [beta]-cells number in offspring of GDM (p<0.05). TUNEL assay showed that the number of apoptotic cells increased in GDM compared to controls (P<0.05). 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This experimental study was designed to determine the effect of gestational diabetes on the [beta]-cellss in 16-week-old rat offspring. By this aim, adult Wistar rats aged 10-12 weeks were randomly allocated in control and diabetic groups. The diabetic group received 40 mg/kg/body weight of streptozotocin (STZ) on day zero of gestation. After delivery, diabetic offspring of GDM mothers and controls at the age of 16 weeks were sacrificed and pancreases harvested and fixed. The number of [beta]-cellss and were counted by Gomori's method staining. Also, apoptosis in pancreas tissue of diabetic and control offspring was detected by TUNEL assay. Results showed a significant reduction in [beta]-cells number in offspring of GDM (p<0.05). TUNEL assay showed that the number of apoptotic cells increased in GDM compared to controls (P<0.05). This study revealed that gestational diabetes induces pancreatic beta-cells apoptosis in 16-week-old rat offspring.</description><subject>Apoptosis</subject><subject>Gestational diabetes</subject><subject>Pancreatic beta cells</subject><subject>Streptozocin</subject><subject>Type 2 diabetes</subject><issn>0717-9367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNzcFuwjAMBuAcQFqBvYMlzhUdoWs5lgIbJxDijkzqokwhrer0vXhEojIQR0625d-feyKIkq8knMvv5EMMmP-iaBonURyI6w-xQ6criwaWGk_kiGFji1b5ukOrGvJrBQtyGOZkDENWV7WrWDNoC1nRGgd7dLAtS64bbc-Tp9Ph6o7fzZfjgsB7rUHucD-bx0MGspA3GruUx33TPUIeiX6Jhunzvw7FeL065L_hGQ0dtS0r16C6aFbHLJazVKZyOpPvpW7ejWAu</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Nazari, Zahra</creator><creator>Nabiuni, Mohammad</creator><creator>Ghaffari, Soraya</creator><creator>Saeidi, Mohsen</creator><creator>Shahriyari, Alireza</creator><creator>Golalipour, Mohammad Jafar</creator><general>Universidad de La Frontera, Facultad de Medicina</general><scope>INF</scope></search><sort><creationdate>20170301</creationdate><title>Gestational Diabetes Induces Pancreatic Beta-Cells Apoptosis in Adult Rat Offspring/Diabetes Gestacional Induce Apoptosis de Celulas Beta del Pancreas en Crias de Ratas Adultas</title><author>Nazari, Zahra ; Nabiuni, Mohammad ; Ghaffari, Soraya ; Saeidi, Mohsen ; Shahriyari, Alireza ; Golalipour, Mohammad Jafar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_infotracmisc_A5348383243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2017</creationdate><topic>Apoptosis</topic><topic>Gestational diabetes</topic><topic>Pancreatic beta cells</topic><topic>Streptozocin</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nazari, Zahra</creatorcontrib><creatorcontrib>Nabiuni, Mohammad</creatorcontrib><creatorcontrib>Ghaffari, Soraya</creatorcontrib><creatorcontrib>Saeidi, Mohsen</creatorcontrib><creatorcontrib>Shahriyari, Alireza</creatorcontrib><creatorcontrib>Golalipour, Mohammad Jafar</creatorcontrib><collection>Gale OneFile: Informe Academico</collection><jtitle>International journal of morphology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nazari, Zahra</au><au>Nabiuni, Mohammad</au><au>Ghaffari, Soraya</au><au>Saeidi, Mohsen</au><au>Shahriyari, Alireza</au><au>Golalipour, Mohammad Jafar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gestational Diabetes Induces Pancreatic Beta-Cells Apoptosis in Adult Rat Offspring/Diabetes Gestacional Induce Apoptosis de Celulas Beta del Pancreas en Crias de Ratas Adultas</atitle><jtitle>International journal of morphology</jtitle><date>2017-03-01</date><risdate>2017</risdate><volume>35</volume><issue>1</issue><spage>16</spage><pages>16-</pages><issn>0717-9367</issn><abstract>Several studies indicated that pancreatic [beta]-cells death occurs in both type 1 and type 2 diabetes. This experimental study was designed to determine the effect of gestational diabetes on the [beta]-cellss in 16-week-old rat offspring. By this aim, adult Wistar rats aged 10-12 weeks were randomly allocated in control and diabetic groups. The diabetic group received 40 mg/kg/body weight of streptozotocin (STZ) on day zero of gestation. After delivery, diabetic offspring of GDM mothers and controls at the age of 16 weeks were sacrificed and pancreases harvested and fixed. The number of [beta]-cellss and were counted by Gomori's method staining. Also, apoptosis in pancreas tissue of diabetic and control offspring was detected by TUNEL assay. Results showed a significant reduction in [beta]-cells number in offspring of GDM (p<0.05). TUNEL assay showed that the number of apoptotic cells increased in GDM compared to controls (P<0.05). This study revealed that gestational diabetes induces pancreatic beta-cells apoptosis in 16-week-old rat offspring.</abstract><pub>Universidad de La Frontera, Facultad de Medicina</pub></addata></record> |
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| ispartof | International journal of morphology, 2017-03, Vol.35 (1), p.16 |
| issn | 0717-9367 |
| language | spa |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Apoptosis Gestational diabetes Pancreatic beta cells Streptozocin Type 2 diabetes |
| title | Gestational Diabetes Induces Pancreatic Beta-Cells Apoptosis in Adult Rat Offspring/Diabetes Gestacional Induce Apoptosis de Celulas Beta del Pancreas en Crias de Ratas Adultas |
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