Transdifferentiation of type II alveolar epithelial cells induces reactivation of dormant tumor cells by enhancing TGF-[beta]/SNAI2 signaling

Dormant tumor cells (DTCs) serve a crucial role in the pathogenesis of metastasis and may compromise the efficacy of existing therapeutic modalities aimed at fully eradicating cancer. However, the mechanisms underlying the dormant-to-proliferating switch of DTCs remain largely unknown. The lung is o...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Oncology reports 2018-04, Vol.39 (4), p.1874
Hauptverfasser:	Zhou, Yuanhong, Gliu, Qian, Dai, Xiangchen, Yan, Yuling, Yang, Ying, Li, Hua, Zhou, Xiaoling, Gao, Wenqi, Li, Xiaolan, Xi, Zuyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Cell differentiation Cellular signal transduction Development and progression Genetic aspects Health aspects Lung cancer Oncogenes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!