F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [[.sup.18]F]FDG-PET/MRI
The current study aimed to determine the optimum diagnostic imaging technique out of magnetic resonance imaging (MRI), [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography ([[.sup.18]F] FDG-PET/CT, otherwise known as PET/CT) and [[.sup.18]F] FDG-PET/MRI (otherwise known as PET...
Gespeichert in:
| Veröffentlicht in: | Oncology letters 2018-03, Vol.15 (3), p.3951 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 3951 |
| container_title | Oncology letters |
| container_volume | 15 |
| creator | Hacker, Marcus Anner, Philip Haug, Alexander Geleff, Silvana Wadsak, Wolfgang Karanikas, Georgios Mayerhofer, Marius Dudczak, Robert |
| description | The current study aimed to determine the optimum diagnostic imaging technique out of magnetic resonance imaging (MRI), [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography ([[.sup.18]F] FDG-PET/CT, otherwise known as PET/CT) and [[.sup.18]F] FDG-PET/MRI (otherwise known as PET/MRI) for the pelvic lymph node staging (N-staging) of untreated cervical carcinoma (CC). A total of 27 patients were included in the present study. All patients had undergone pre-treatment with PET/CT and MRI [less than or equal to]45 days prior to undergoing a lymphadenectomy. The results from PET (separated from PET/CT), MRI and the statistically combined results of (virtual) PET/MRI were compared to those from histological analyses (the gold standard). A per-patient-based analysis of the detection of pelvic lymph node metastases indicated that PET/MRI had a sensitivity of 64%. The specificity of PET/CT and MRI were 69 and 62%, respectively. The positive predictive value (PPV) was 69 and 64% for PET/CT and MRI, respectively. The negative predictive value (NPV) was 64 and 62% for PET/CT and MRI, respectively. The sensitivity of the PET-guided PET/MRI and the MRI-guided PET/MRI was 64% for both. The specificity of the PET-guided PET/MRI and the MRI-guided PET/MRI was 77 and 62%, respectively. The PPV was 75% for PET-guided PET/MRI and 64% for MRI-guided PET/MRI, and the NPV was 67 and 62%, respectively. PET/CT and the virtual PET/MRI exhibited the same low sensitivity (64%). PET/MRI exhibited slightly better results than PET/CT regarding specificity (77 vs. 69%, respectively), PPV (75 vs. 69%, respectively) and NPV (67 vs. 64%, respectively). The results of the present study suggested that PET/CT and MRI are not optimal diagnostic modalities, and that PET/MRI does not necessarily lead to better results than PET/CT, in the pelvic N-staging of CC. Key words: pelvic nodal staging, cervical carcinoma, [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography, magnetic resonance imaging, positron emission tomography/magnetic resonance imaging |
| doi_str_mv | 10.3892/ol.2018.7775 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A533095516</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A533095516</galeid><sourcerecordid>A533095516</sourcerecordid><originalsourceid>FETCH-LOGICAL-g596-4aa5b828a1413fdb718dde6a2fb38edb150ace0ef2b037ba5c6711641105948a3</originalsourceid><addsrcrecordid>eNpNzkFLwzAUB_AcFBxzNz9AQPDWLmmbNvU25jYHE0V6G2O8tkkbyZLSpIqfwy9sRcG9y7v8_v_3ELqhJIx5Hs2tDiNCeZhlGbtAE5rlUUBJllyhmXNvZByWUs7TCfpaH9YPm-BlVcyXBQZT46fXLZa2x8oor0DjTuh3VWH9eepabGwtsPPQKNOMAnfglTDe4Q_lW1yJfqRjpoK-Usae4B4XrcCd9SP6KRuckIM2wjlsJd7vQzd0IeWH_y_G89foUoJ2Yva3p6hYr4rlY7B73myXi13QsDwNEgBW8ogDTWgs6zKjvK5FCpEsYy7qkjIClSBCRiWJsxJYlWaUpgmlhOUJh3iKbn9rG9DiqIy0vofqpFx1XLA4JjljNB3V3ZlqBWjfOqsHr6xx5_AbVXhxRQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [[.sup.18]F]FDG-PET/MRI</title><source>Spandidos Publications Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Hacker, Marcus ; Anner, Philip ; Haug, Alexander ; Geleff, Silvana ; Wadsak, Wolfgang ; Karanikas, Georgios ; Mayerhofer, Marius ; Dudczak, Robert</creator><creatorcontrib>Hacker, Marcus ; Anner, Philip ; Haug, Alexander ; Geleff, Silvana ; Wadsak, Wolfgang ; Karanikas, Georgios ; Mayerhofer, Marius ; Dudczak, Robert</creatorcontrib><description>The current study aimed to determine the optimum diagnostic imaging technique out of magnetic resonance imaging (MRI), [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography ([[.sup.18]F] FDG-PET/CT, otherwise known as PET/CT) and [[.sup.18]F] FDG-PET/MRI (otherwise known as PET/MRI) for the pelvic lymph node staging (N-staging) of untreated cervical carcinoma (CC). A total of 27 patients were included in the present study. All patients had undergone pre-treatment with PET/CT and MRI [less than or equal to]45 days prior to undergoing a lymphadenectomy. The results from PET (separated from PET/CT), MRI and the statistically combined results of (virtual) PET/MRI were compared to those from histological analyses (the gold standard). A per-patient-based analysis of the detection of pelvic lymph node metastases indicated that PET/MRI had a sensitivity of 64%. The specificity of PET/CT and MRI were 69 and 62%, respectively. The positive predictive value (PPV) was 69 and 64% for PET/CT and MRI, respectively. The negative predictive value (NPV) was 64 and 62% for PET/CT and MRI, respectively. The sensitivity of the PET-guided PET/MRI and the MRI-guided PET/MRI was 64% for both. The specificity of the PET-guided PET/MRI and the MRI-guided PET/MRI was 77 and 62%, respectively. The PPV was 75% for PET-guided PET/MRI and 64% for MRI-guided PET/MRI, and the NPV was 67 and 62%, respectively. PET/CT and the virtual PET/MRI exhibited the same low sensitivity (64%). PET/MRI exhibited slightly better results than PET/CT regarding specificity (77 vs. 69%, respectively), PPV (75 vs. 69%, respectively) and NPV (67 vs. 64%, respectively). The results of the present study suggested that PET/CT and MRI are not optimal diagnostic modalities, and that PET/MRI does not necessarily lead to better results than PET/CT, in the pelvic N-staging of CC. Key words: pelvic nodal staging, cervical carcinoma, [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography, magnetic resonance imaging, positron emission tomography/magnetic resonance imaging</description><identifier>ISSN: 1792-1074</identifier><identifier>DOI: 10.3892/ol.2018.7775</identifier><language>eng</language><publisher>Spandidos Publications</publisher><subject>Care and treatment ; Cervical cancer ; Diagnosis ; Magnetic resonance imaging ; Positron emission tomography</subject><ispartof>Oncology letters, 2018-03, Vol.15 (3), p.3951</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Hacker, Marcus</creatorcontrib><creatorcontrib>Anner, Philip</creatorcontrib><creatorcontrib>Haug, Alexander</creatorcontrib><creatorcontrib>Geleff, Silvana</creatorcontrib><creatorcontrib>Wadsak, Wolfgang</creatorcontrib><creatorcontrib>Karanikas, Georgios</creatorcontrib><creatorcontrib>Mayerhofer, Marius</creatorcontrib><creatorcontrib>Dudczak, Robert</creatorcontrib><title>F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [[.sup.18]F]FDG-PET/MRI</title><title>Oncology letters</title><description>The current study aimed to determine the optimum diagnostic imaging technique out of magnetic resonance imaging (MRI), [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography ([[.sup.18]F] FDG-PET/CT, otherwise known as PET/CT) and [[.sup.18]F] FDG-PET/MRI (otherwise known as PET/MRI) for the pelvic lymph node staging (N-staging) of untreated cervical carcinoma (CC). A total of 27 patients were included in the present study. All patients had undergone pre-treatment with PET/CT and MRI [less than or equal to]45 days prior to undergoing a lymphadenectomy. The results from PET (separated from PET/CT), MRI and the statistically combined results of (virtual) PET/MRI were compared to those from histological analyses (the gold standard). A per-patient-based analysis of the detection of pelvic lymph node metastases indicated that PET/MRI had a sensitivity of 64%. The specificity of PET/CT and MRI were 69 and 62%, respectively. The positive predictive value (PPV) was 69 and 64% for PET/CT and MRI, respectively. The negative predictive value (NPV) was 64 and 62% for PET/CT and MRI, respectively. The sensitivity of the PET-guided PET/MRI and the MRI-guided PET/MRI was 64% for both. The specificity of the PET-guided PET/MRI and the MRI-guided PET/MRI was 77 and 62%, respectively. The PPV was 75% for PET-guided PET/MRI and 64% for MRI-guided PET/MRI, and the NPV was 67 and 62%, respectively. PET/CT and the virtual PET/MRI exhibited the same low sensitivity (64%). PET/MRI exhibited slightly better results than PET/CT regarding specificity (77 vs. 69%, respectively), PPV (75 vs. 69%, respectively) and NPV (67 vs. 64%, respectively). The results of the present study suggested that PET/CT and MRI are not optimal diagnostic modalities, and that PET/MRI does not necessarily lead to better results than PET/CT, in the pelvic N-staging of CC. Key words: pelvic nodal staging, cervical carcinoma, [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography, magnetic resonance imaging, positron emission tomography/magnetic resonance imaging</description><subject>Care and treatment</subject><subject>Cervical cancer</subject><subject>Diagnosis</subject><subject>Magnetic resonance imaging</subject><subject>Positron emission tomography</subject><issn>1792-1074</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNpNzkFLwzAUB_AcFBxzNz9AQPDWLmmbNvU25jYHE0V6G2O8tkkbyZLSpIqfwy9sRcG9y7v8_v_3ELqhJIx5Hs2tDiNCeZhlGbtAE5rlUUBJllyhmXNvZByWUs7TCfpaH9YPm-BlVcyXBQZT46fXLZa2x8oor0DjTuh3VWH9eepabGwtsPPQKNOMAnfglTDe4Q_lW1yJfqRjpoK-Usae4B4XrcCd9SP6KRuckIM2wjlsJd7vQzd0IeWH_y_G89foUoJ2Yva3p6hYr4rlY7B73myXi13QsDwNEgBW8ogDTWgs6zKjvK5FCpEsYy7qkjIClSBCRiWJsxJYlWaUpgmlhOUJh3iKbn9rG9DiqIy0vofqpFx1XLA4JjljNB3V3ZlqBWjfOqsHr6xx5_AbVXhxRQ</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Hacker, Marcus</creator><creator>Anner, Philip</creator><creator>Haug, Alexander</creator><creator>Geleff, Silvana</creator><creator>Wadsak, Wolfgang</creator><creator>Karanikas, Georgios</creator><creator>Mayerhofer, Marius</creator><creator>Dudczak, Robert</creator><general>Spandidos Publications</general><scope/></search><sort><creationdate>20180301</creationdate><title>F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [[.sup.18]F]FDG-PET/MRI</title><author>Hacker, Marcus ; Anner, Philip ; Haug, Alexander ; Geleff, Silvana ; Wadsak, Wolfgang ; Karanikas, Georgios ; Mayerhofer, Marius ; Dudczak, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g596-4aa5b828a1413fdb718dde6a2fb38edb150ace0ef2b037ba5c6711641105948a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Care and treatment</topic><topic>Cervical cancer</topic><topic>Diagnosis</topic><topic>Magnetic resonance imaging</topic><topic>Positron emission tomography</topic><toplevel>online_resources</toplevel><creatorcontrib>Hacker, Marcus</creatorcontrib><creatorcontrib>Anner, Philip</creatorcontrib><creatorcontrib>Haug, Alexander</creatorcontrib><creatorcontrib>Geleff, Silvana</creatorcontrib><creatorcontrib>Wadsak, Wolfgang</creatorcontrib><creatorcontrib>Karanikas, Georgios</creatorcontrib><creatorcontrib>Mayerhofer, Marius</creatorcontrib><creatorcontrib>Dudczak, Robert</creatorcontrib><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hacker, Marcus</au><au>Anner, Philip</au><au>Haug, Alexander</au><au>Geleff, Silvana</au><au>Wadsak, Wolfgang</au><au>Karanikas, Georgios</au><au>Mayerhofer, Marius</au><au>Dudczak, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [[.sup.18]F]FDG-PET/MRI</atitle><jtitle>Oncology letters</jtitle><date>2018-03-01</date><risdate>2018</risdate><volume>15</volume><issue>3</issue><spage>3951</spage><pages>3951-</pages><issn>1792-1074</issn><abstract>The current study aimed to determine the optimum diagnostic imaging technique out of magnetic resonance imaging (MRI), [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography ([[.sup.18]F] FDG-PET/CT, otherwise known as PET/CT) and [[.sup.18]F] FDG-PET/MRI (otherwise known as PET/MRI) for the pelvic lymph node staging (N-staging) of untreated cervical carcinoma (CC). A total of 27 patients were included in the present study. All patients had undergone pre-treatment with PET/CT and MRI [less than or equal to]45 days prior to undergoing a lymphadenectomy. The results from PET (separated from PET/CT), MRI and the statistically combined results of (virtual) PET/MRI were compared to those from histological analyses (the gold standard). A per-patient-based analysis of the detection of pelvic lymph node metastases indicated that PET/MRI had a sensitivity of 64%. The specificity of PET/CT and MRI were 69 and 62%, respectively. The positive predictive value (PPV) was 69 and 64% for PET/CT and MRI, respectively. The negative predictive value (NPV) was 64 and 62% for PET/CT and MRI, respectively. The sensitivity of the PET-guided PET/MRI and the MRI-guided PET/MRI was 64% for both. The specificity of the PET-guided PET/MRI and the MRI-guided PET/MRI was 77 and 62%, respectively. The PPV was 75% for PET-guided PET/MRI and 64% for MRI-guided PET/MRI, and the NPV was 67 and 62%, respectively. PET/CT and the virtual PET/MRI exhibited the same low sensitivity (64%). PET/MRI exhibited slightly better results than PET/CT regarding specificity (77 vs. 69%, respectively), PPV (75 vs. 69%, respectively) and NPV (67 vs. 64%, respectively). The results of the present study suggested that PET/CT and MRI are not optimal diagnostic modalities, and that PET/MRI does not necessarily lead to better results than PET/CT, in the pelvic N-staging of CC. Key words: pelvic nodal staging, cervical carcinoma, [.sup.18]F-fludeoxyglucose positron emission tomography/computed tomography, magnetic resonance imaging, positron emission tomography/magnetic resonance imaging</abstract><pub>Spandidos Publications</pub><doi>10.3892/ol.2018.7775</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1792-1074 |
| ispartof | Oncology letters, 2018-03, Vol.15 (3), p.3951 |
| issn | 1792-1074 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A533095516 |
| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Care and treatment Cervical cancer Diagnosis Magnetic resonance imaging Positron emission tomography |
| title | F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [[.sup.18]F]FDG-PET/MRI |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T11%3A32%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=F%5DFDG-PET/CT%20and%20MRI%20for%20initial%20pelvic%20lymph%20node%20staging%20in%20patients%20with%20cervical%20carcinoma:%20The%20potential%20usefulness%20of%20%5B%5B.sup.18%5DF%5DFDG-PET/MRI&rft.jtitle=Oncology%20letters&rft.au=Hacker,%20Marcus&rft.date=2018-03-01&rft.volume=15&rft.issue=3&rft.spage=3951&rft.pages=3951-&rft.issn=1792-1074&rft_id=info:doi/10.3892/ol.2018.7775&rft_dat=%3Cgale%3EA533095516%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A533095516&rfr_iscdi=true |