Effects of Kagocel® on the Counts of Multipotent Stromal Cells, Expression of Cytokine Genes in Primary Cultures of Bone Marrow Stromal Cells, and Serum Cytokine Concentrations in CBA Mice

The efficiency of cloning of bone marrow multipotent stromal cells (ECF-MSC) from CBA mice and the MSC counts in the femoral bone increased 24 h after a single in vivo (but not in vitro ) injection of kagocel (active substance of antiviral drug Kagocel ® ) 1.4 times (in response to 50-80 μg) and 4.6...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-06, Vol.159 (2), p.240-244
Hauptverfasser:	Gorskaya, Yu. F., Grabko, V. I., Konopleva, M. V., Suslov, A. P., Nesterenko, V. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antiviral Agents - pharmacology Azure Stains B cells Biological response modifiers Biomedical and Life Sciences Biomedicine Cell Biology Cell Culture Techniques Cell Proliferation - drug effects Cytokines - blood Cytokines - genetics Cytokines - metabolism Dose-Response Relationship, Drug Eosine Yellowish-(YS) Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Genes Gossypol - administration & dosage Gossypol - analogs & derivatives Gossypol - pharmacology Histological Techniques Injections, Intraperitoneal Interferon Internal Medicine Laboratory Medicine Male Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred CBA Pathology Poly I-C - administration & dosage Poly I-C - pharmacology Time Factors
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