Synthesis, Docking, and Anticoagulant Activity of New Factor-Xa Inhibitors in a Series of Pyrrolo[3,2,1-ij]Quinoline-1,2-Diones
New factor-Xa inhibitors in a series of pyrrolo[3,2,1- ij ]quinoline-1,2-diones substituted by condensation at the β-carbonyl with rhodanine, arylamines, and H -tryptamines were synthesized, characterized, and studied by molecular docking. Promising factor-Xa inhibitors with inhibitory constants in...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2018-02, Vol.51 (11), p.975-979 |
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| container_issue | 11 |
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| container_title | Pharmaceutical chemistry journal |
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| creator | Medvedeva, S. M. Potapov, A. Yu Gribkova, I. V. Katkova, E. V. Sulimov, V. B. Shikhaliev, Kh. S. |
| description | New factor-Xa inhibitors in a series of pyrrolo[3,2,1-
ij
]quinoline-1,2-diones substituted by condensation at the β-carbonyl with rhodanine, arylamines, and
H
-tryptamines were synthesized, characterized, and studied by molecular docking. Promising factor-Xa inhibitors with inhibitory constants in the micromolar concentration range (IC
50
= 0.7 – 40 μM) were discovered. |
| doi_str_mv | 10.1007/s11094-018-1726-4 |
| format | Article |
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| ispartof | Pharmaceutical chemistry journal, 2018-02, Vol.51 (11), p.975-979 |
| issn | 0091-150X 1573-9031 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Alkaloids Anticoagulants Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy Quinoline Thrombin |
| title | Synthesis, Docking, and Anticoagulant Activity of New Factor-Xa Inhibitors in a Series of Pyrrolo[3,2,1-ij]Quinoline-1,2-Diones |
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