A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-[kappa]B signaling

Poxviruses have evolved multiple strategies to subvert signaling by Nuclear Factor [kappa]B (NF-[kappa]B), a crucial regulator of host innate immune responses. Here, we describe an orf virus (ORFV) virion-associated protein, ORFV119, which inhibits NF-[kappa]B signaling very early in infection ([les...

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Veröffentlicht in:	PLoS pathogens 2017-12, Vol.13 (12)
Hauptverfasser:	Nagendraprabhu, Ponnuraj, Khatiwada, Sushil, Chaulagain, Sabal, Delhon, Gustavo, Rock, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Development and progression Health aspects Physiological aspects Poxviruses Retinoblastoma Transcription factors Tumor proteins Viral proteins
Online-Zugang:	Volltext
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