Heterozygous deletion of both sclerostin genes in mice is not sufficient to impair cortical bone modeling

Connexin43 (Cx43) is the main gap junction protein expressed in bone forming cells, where it modulates peak bone mass acquisition and cortical modeling. Genetic ablation of the Cx43 gene (Gja1) results in cortical expansion with accentuated periosteal bone formation associated with decreased express...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187980
Hauptverfasser:	Grimston, Susan K, Fontana, Francesca, Watkins, Marcus, Civitelli, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Bones Density Genetic aspects Membrane proteins Physiological aspects
Online-Zugang:	Volltext
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