Influence of [ACTG.sub.4-7]-PGP on morphofunctional state of hepatocytes in chronic emotional and painful stress
We studied the effect of intraperitoneal administration of peptide [ACTG.sub.4-7]-PGP to male Wistar rats in doses of 5, 50, 150, and 450 [micro]g/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress. A dose-dependent stress-limiting effect of the peptide was obser...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017-05, Vol.163 (1), p.105 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Ivanov, A.V Bobyntsev, I.I Shepeleva, O.M Kryukov, A.A Andreeva, L.A Myasoedov, N.F |
| description | We studied the effect of intraperitoneal administration of peptide [ACTG.sub.4-7]-PGP to male Wistar rats in doses of 5, 50, 150, and 450 [micro]g/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress. A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver and serum activity of ALT. The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration. The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein. Key Words: [ACTG.sub.4-7]-PGP (Semax); emotional and painful stress; liver; aminotransferase; degeneration of the liver |
| doi_str_mv | 10.1007/s10517-017-3748-4 |
| format | Article |
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A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver and serum activity of ALT. The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration. The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein. 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A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver and serum activity of ALT. The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration. The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein. 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| subjects | Blood proteins Peptides Protein synthesis Stress (Psychology) |
| title | Influence of [ACTG.sub.4-7]-PGP on morphofunctional state of hepatocytes in chronic emotional and painful stress |
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