Clitocine Reversal of P-Glycoprotein Associated Multi-Drug Resistance through Down-Regulation of Transcription Factor NF-[kappa]B in R-HepG2 Cell Line

Multidrug resistance(MDR)is one of the major reasons for failure in cancer chemotherapy and its suppression may increase the efficacy of therapy. The human multidrug resistance 1 (MDR1) gene encodes the plasma membrane P-glycoprotein (P-gp) that pumps various anti-cancer agents out of the cancer cel...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e40720
Hauptverfasser:	Sun, Jianguo, Yeung, Chilam Au, Co, Ngai Na, Tsang, Tsun Yee, Yau, Esmond, Luo, Kewang, Wu, Ping, Wa, Judy Chan Yuet, Fung, Kwok-Pui, Kwok, Tim-Tak, Liu, Feiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anthracyclines Chemotherapy Diagnosis Dosage and administration Doxorubicin Hepatocellular carcinoma Microbial drug resistance
Online-Zugang:	Volltext
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