Pentosan polysulfate inhibits IL-1[beta]-induced iNOS, c-Jun and HIF-1[alpha] upregulation in canine articular chondrocytes

Osteoarthritic (OA) chondrocytes are shown to express inducible nitric oxide synthase (iNOS) which produces high concentrations of nitric oxide (NO), particularly when stimulated with proinflammatory cytokines. NO is involved in OA cartilage degradation. On the other hand, c-Jun N-terminal Kinase (J...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0177144
Hauptverfasser:	Bwalya, Eugene C, Kim, Sangho, Fang, Jing, Wijekoon, H. M. Suranji, Hosoya, Kenji, Okumura, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Health aspects Interleukins Nitric oxide Osteoarthritis Physiological aspects Risk factors
Online-Zugang:	Volltext
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