Down-Regulation of Gli Transcription Factor Leads to the Inhibition of Migration and Invasion of Ovarian Cancer Cells via Integrin [beta]4-Mediated FAK Signaling

Recent evidence suggests that aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas including ovarian cancer. Therefore, chemotherapeutic agents that inhibit activation of Gli transcription factors have emerged as pr...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e88386
Hauptverfasser:	Chen, Qi, Xu, Rong, Zeng, Chunyan, Lu, Quqin, Huang, Dengliang, Shi, Chao, Zhang, Weilong, Deng, Libin, Yan, Runwei, Rao, Hai, Gao, Guolan, Luo, Shiwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cancer cells Chemotherapy Development and progression DNA binding proteins DNA microarrays Genes Genetic research Health aspects Integrins Ovarian cancer
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!