Utility of R.sub.2 Obtained from T.sub.2-Weighted Imaging in Differentiating Hepatocellular Carcinomas from Cavernous Hemangiomas of the Liver
To evaluate the feasibility of applying R.sub.2 * values to differentiate hepatocellular carcinomas (HCC) from cavernous hemangiomas of the liver (CHL). This retrospective study was approved by the participating Institutional Review Board and written informed consent for all subjects were obtained....
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e91751 |
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| creator | Sun, Meiyu Wang, Sheng Song, Qingwei Wang, Zhiyuan Wang, Heqing Ning, Dianxiu Xu, Bin Wei, Qiang Liu, Ailian |
| description | To evaluate the feasibility of applying R.sub.2 * values to differentiate hepatocellular carcinomas (HCC) from cavernous hemangiomas of the liver (CHL). This retrospective study was approved by the participating Institutional Review Board and written informed consent for all subjects were obtained. Seventy-three patients with 79 pathologically identified HCCs and 65 patients with 91 clinically or pathologically identified CHLs were enrolled in this study. All subjects underwent a breath-hold multi-echo T.sub.2 * weighted MR imaging on a 1.5T clinical MR scanner. R.sub.2 * values from HCC and CHL groups were compared using the Mann-Whitney non-parametric U test. A cut-off value of R.sub.2 * was evaluated with receiver operator characteristic (ROC) analysis. The mean R.sub.2 * value was 23.32±12.23 Hz (95% confidence interval [CI]: 20.58 Hz, 26.06 Hz) for the HCC group, and 3.66±2.37 Hz (95% CI: 3.17 Hz, 4.15 Hz) for the CHL group. The mean R.sub.2 * value for HCC was significantly higher than that of CHL (p |
| doi_str_mv | 10.1371/journal.pone.0091751 |
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This retrospective study was approved by the participating Institutional Review Board and written informed consent for all subjects were obtained. Seventy-three patients with 79 pathologically identified HCCs and 65 patients with 91 clinically or pathologically identified CHLs were enrolled in this study. All subjects underwent a breath-hold multi-echo T.sub.2 * weighted MR imaging on a 1.5T clinical MR scanner. R.sub.2 * values from HCC and CHL groups were compared using the Mann-Whitney non-parametric U test. A cut-off value of R.sub.2 * was evaluated with receiver operator characteristic (ROC) analysis. The mean R.sub.2 * value was 23.32±12.23 Hz (95% confidence interval [CI]: 20.58 Hz, 26.06 Hz) for the HCC group, and 3.66±2.37 Hz (95% CI: 3.17 Hz, 4.15 Hz) for the CHL group. The mean R.sub.2 * value for HCC was significantly higher than that of CHL (p<0.001). A threshold of 9.48 Hz for the minimum R.sub.2 * value in the diagnosis of HCC resulted in a sensitivity of 96.20% (76 out of 79 patients), and a specificity of 97.80% (89 out of 91 patients). The positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy for HCC were 97.44% (76 out of 78 patients), 96.74% (89 out of 92 patients) and 97.06% (165 out of 170 patients), respectively. The AUC for differentiation between these two groups was 0.994 (95% CI: 0.980, 1.000). R.sub.2 * is a significant MRI biomarker to differentiate HCC from CHL with satisfying sensitivity and specificity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0091751</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Cancer ; Diagnostic imaging ; Hemangioma ; Medical research</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e91751</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Sun, Meiyu</creatorcontrib><creatorcontrib>Wang, Sheng</creatorcontrib><creatorcontrib>Song, Qingwei</creatorcontrib><creatorcontrib>Wang, Zhiyuan</creatorcontrib><creatorcontrib>Wang, Heqing</creatorcontrib><creatorcontrib>Ning, Dianxiu</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><creatorcontrib>Wei, Qiang</creatorcontrib><creatorcontrib>Liu, Ailian</creatorcontrib><title>Utility of R.sub.2 Obtained from T.sub.2-Weighted Imaging in Differentiating Hepatocellular Carcinomas from Cavernous Hemangiomas of the Liver</title><title>PloS one</title><description>To evaluate the feasibility of applying R.sub.2 * values to differentiate hepatocellular carcinomas (HCC) from cavernous hemangiomas of the liver (CHL). This retrospective study was approved by the participating Institutional Review Board and written informed consent for all subjects were obtained. Seventy-three patients with 79 pathologically identified HCCs and 65 patients with 91 clinically or pathologically identified CHLs were enrolled in this study. All subjects underwent a breath-hold multi-echo T.sub.2 * weighted MR imaging on a 1.5T clinical MR scanner. R.sub.2 * values from HCC and CHL groups were compared using the Mann-Whitney non-parametric U test. A cut-off value of R.sub.2 * was evaluated with receiver operator characteristic (ROC) analysis. The mean R.sub.2 * value was 23.32±12.23 Hz (95% confidence interval [CI]: 20.58 Hz, 26.06 Hz) for the HCC group, and 3.66±2.37 Hz (95% CI: 3.17 Hz, 4.15 Hz) for the CHL group. The mean R.sub.2 * value for HCC was significantly higher than that of CHL (p<0.001). A threshold of 9.48 Hz for the minimum R.sub.2 * value in the diagnosis of HCC resulted in a sensitivity of 96.20% (76 out of 79 patients), and a specificity of 97.80% (89 out of 91 patients). The positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy for HCC were 97.44% (76 out of 78 patients), 96.74% (89 out of 92 patients) and 97.06% (165 out of 170 patients), respectively. The AUC for differentiation between these two groups was 0.994 (95% CI: 0.980, 1.000). R.sub.2 * is a significant MRI biomarker to differentiate HCC from CHL with satisfying sensitivity and specificity.</description><subject>Cancer</subject><subject>Diagnostic imaging</subject><subject>Hemangioma</subject><subject>Medical research</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkE1LxDAQhoso-PkPPAQEwUNr06RJe5T1a2FhQV09LtNs0s2SJtKkon_C32x0PeyCB5nDDO887wy8SXKK8wwTji9XbugtmOzVWZnleY15iXeSA1yTImVFTnY35v3k0PtVnpekYuwg-ZwFbXT4QE6hh8wPTVagaRNAW7lAqncdelqr6YvU7TJEddxBq22LtEXXWinZSxs0hG_pXr5CcEIaMxjo0Qh6oa3rwK9PjeBN9tYNPoId2Fb_rOLnsJRoouPyONlTYLw8-e1Hyez25ml0n06md-PR1SRtMWNFSisQGEQjKKOE16ypc4FpxUCWkpQFVhy4wmpRU8F5SZiii5rQhtOqaHgMgRwlZ-u7LRg511a50IPotBfzK8orzkheF5HK_qBiLWSnRQxb6ahvGS62DJEJ8j20MHg_Hz8-_J-dPm-z5xvsUoIJS-_MELSzfhP8AhwZoU4</recordid><startdate>20140314</startdate><enddate>20140314</enddate><creator>Sun, Meiyu</creator><creator>Wang, Sheng</creator><creator>Song, Qingwei</creator><creator>Wang, Zhiyuan</creator><creator>Wang, Heqing</creator><creator>Ning, Dianxiu</creator><creator>Xu, Bin</creator><creator>Wei, Qiang</creator><creator>Liu, Ailian</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20140314</creationdate><title>Utility of R.sub.2 Obtained from T.sub.2-Weighted Imaging in Differentiating Hepatocellular Carcinomas from Cavernous Hemangiomas of the Liver</title><author>Sun, Meiyu ; Wang, Sheng ; Song, Qingwei ; Wang, Zhiyuan ; Wang, Heqing ; Ning, Dianxiu ; Xu, Bin ; Wei, Qiang ; Liu, Ailian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1662-48ac1acbc4643796b90c1486ae5e3521f7a7f1fd94c77536f4d934b7482b72033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cancer</topic><topic>Diagnostic imaging</topic><topic>Hemangioma</topic><topic>Medical research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Meiyu</creatorcontrib><creatorcontrib>Wang, Sheng</creatorcontrib><creatorcontrib>Song, Qingwei</creatorcontrib><creatorcontrib>Wang, Zhiyuan</creatorcontrib><creatorcontrib>Wang, Heqing</creatorcontrib><creatorcontrib>Ning, Dianxiu</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><creatorcontrib>Wei, Qiang</creatorcontrib><creatorcontrib>Liu, Ailian</creatorcontrib><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Meiyu</au><au>Wang, Sheng</au><au>Song, Qingwei</au><au>Wang, Zhiyuan</au><au>Wang, Heqing</au><au>Ning, Dianxiu</au><au>Xu, Bin</au><au>Wei, Qiang</au><au>Liu, Ailian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of R.sub.2 Obtained from T.sub.2-Weighted Imaging in Differentiating Hepatocellular Carcinomas from Cavernous Hemangiomas of the Liver</atitle><jtitle>PloS one</jtitle><date>2014-03-14</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e91751</spage><pages>e91751-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate the feasibility of applying R.sub.2 * values to differentiate hepatocellular carcinomas (HCC) from cavernous hemangiomas of the liver (CHL). This retrospective study was approved by the participating Institutional Review Board and written informed consent for all subjects were obtained. Seventy-three patients with 79 pathologically identified HCCs and 65 patients with 91 clinically or pathologically identified CHLs were enrolled in this study. All subjects underwent a breath-hold multi-echo T.sub.2 * weighted MR imaging on a 1.5T clinical MR scanner. R.sub.2 * values from HCC and CHL groups were compared using the Mann-Whitney non-parametric U test. A cut-off value of R.sub.2 * was evaluated with receiver operator characteristic (ROC) analysis. The mean R.sub.2 * value was 23.32±12.23 Hz (95% confidence interval [CI]: 20.58 Hz, 26.06 Hz) for the HCC group, and 3.66±2.37 Hz (95% CI: 3.17 Hz, 4.15 Hz) for the CHL group. The mean R.sub.2 * value for HCC was significantly higher than that of CHL (p<0.001). A threshold of 9.48 Hz for the minimum R.sub.2 * value in the diagnosis of HCC resulted in a sensitivity of 96.20% (76 out of 79 patients), and a specificity of 97.80% (89 out of 91 patients). The positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy for HCC were 97.44% (76 out of 78 patients), 96.74% (89 out of 92 patients) and 97.06% (165 out of 170 patients), respectively. The AUC for differentiation between these two groups was 0.994 (95% CI: 0.980, 1.000). R.sub.2 * is a significant MRI biomarker to differentiate HCC from CHL with satisfying sensitivity and specificity.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0091751</doi><tpages>e91751</tpages></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Cancer Diagnostic imaging Hemangioma Medical research |
| title | Utility of R.sub.2 Obtained from T.sub.2-Weighted Imaging in Differentiating Hepatocellular Carcinomas from Cavernous Hemangiomas of the Liver |
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