11[beta]-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE.sup.-/- Mice

Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11[beta]-hydroxysteroid dehydrogenase type 1 (11[beta]HSD1) increases active glucocorticoid levels within tissues by catalyzing the conversion of cortisone to cortisol. Ph...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e53192
Hauptverfasser:	García, Ricardo A, Search, Debra J, Lupisella, John A, Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E, Gargalovic, Peter S, Ryan, Carol S, Watson, Linda M, Langish, Robert A, Shipkova, Petia A, Carson, Nancy L, Taylor, Joseph R, Yang, Richard, Psaltis, George C, Harrity, Thomas W, Robl, Jeffrey A, Gordon, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Genetic aspects Glucocorticoids Risk factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!