Reduction in ATP Levels Triggers Immunoproteasome Activation by the 11S Regulator during Early Antiviral Response Mediated by IFN[beta] in Mouse Pancreatic [beta]-Cells

Autoimmune destruction of insulin producing pancreatic [beta]-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with the constitutive 19S and the inducible 11S (PA28...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e52408
Hauptverfasser:	Freudenburg, Wieke, Gautam, Madhav, Chakraborty, Pradipta, James, Jared, Richards, Jennifer, Salvatori, Alison S, Baldwin, Aaron, Schriewer, Jill, Buller, R. Mark L, Corbett, John A, Skowyra, Dorota
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological markers Interferon Pancreatic beta cells Polymerase chain reaction
Online-Zugang:	Volltext
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