Mouse Hepatic Oval Cells Require Met-Dependent PI3K to Impair TGF-[beta]-Induced Oxidative Stress and Apoptosis

We have previously shown that oval cells harboring a genetically inactivated Met tyrosine kinase (Met.sup.-/- oval cells) are more sensitive to TGF-[beta]-induced apoptosis than cells expressing a functional Met (Met.sup.flx/flx ), demonstrating that the HGF/Met axis plays a pivotal role in oval cel...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53108
Hauptverfasser:	Martínez-Palacián, Adoración, del Castillo, Gaelle, Suárez-Causado, Amileth, García-Álvaro, María, Morena-Frutos, Diego de la, Fernández, Margarita, Roncero, Cesáreo, Fabregat, Isabel, Herrera, Blanca, Sánchez, Aránzazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Hepatocytes Oxidative stress Transforming growth factors
Online-Zugang:	Volltext
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