PECAM1.sup.+/Sca1.sup.+/CD38.sup.+ Vascular Cells Transform into Myofibroblast-Like Cells in Skin Wound Repair
Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may also differentiate into matrix-secreting contractile myofibroblasts to promote wound closure. Here, we characterize a PECAM1.sup.+ /Sca1.sup.+ vascular cell...
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| Veröffentlicht in: | PloS one 2013-01, Vol.8 (1), p.e53262 |
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| creator | Etich, Julia Bergmeier, Vera Frie, Christian Kreft, Sandra Bengestrate, Lena Eming, Sabine Mauch, Cornelia Eckes, Beate Ulus, Hikmet Lund, Frances E Rappl, Gunter Abken, Hinrich Paulsson, Mats Brachvogel, Bent |
| description | Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may also differentiate into matrix-secreting contractile myofibroblasts to promote wound closure. Here, we characterize a PECAM1.sup.+ /Sca1.sup.+ vascular cell population in mouse skin, which is highly enriched in wounds at the peak of neoangiogenesis and myofibroblast formation. These cells express endothelial and perivascular markers and present the receptor CD38 on their surface. PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ cells proliferate upon wounding and could give rise to [alpha]-SMA.sup.+ myofibroblast-like cells. CD38 stimulation in immunodeficient mice reduced the wound size at the peak of neoangiogenesis and myofibroblast formation. In humans a corresponding cell population was identified, which was enriched in sprouting vessels of basal cell carcinoma biopsies. The results indicate that PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ vascular cells could proliferate and differentiate into myofibroblast-like cells in wound repair. Moreover, CD38 signaling modulates PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ cell activation in the healing process implying CD38 as a target for anti-angiogenic therapies in human basal cell carcinoma. |
| doi_str_mv | 10.1371/journal.pone.0053262 |
| format | Article |
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Vascular cells may also differentiate into matrix-secreting contractile myofibroblasts to promote wound closure. Here, we characterize a PECAM1.sup.+ /Sca1.sup.+ vascular cell population in mouse skin, which is highly enriched in wounds at the peak of neoangiogenesis and myofibroblast formation. These cells express endothelial and perivascular markers and present the receptor CD38 on their surface. PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ cells proliferate upon wounding and could give rise to [alpha]-SMA.sup.+ myofibroblast-like cells. CD38 stimulation in immunodeficient mice reduced the wound size at the peak of neoangiogenesis and myofibroblast formation. In humans a corresponding cell population was identified, which was enriched in sprouting vessels of basal cell carcinoma biopsies. The results indicate that PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ vascular cells could proliferate and differentiate into myofibroblast-like cells in wound repair. 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Vascular cells may also differentiate into matrix-secreting contractile myofibroblasts to promote wound closure. Here, we characterize a PECAM1.sup.+ /Sca1.sup.+ vascular cell population in mouse skin, which is highly enriched in wounds at the peak of neoangiogenesis and myofibroblast formation. These cells express endothelial and perivascular markers and present the receptor CD38 on their surface. PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ cells proliferate upon wounding and could give rise to [alpha]-SMA.sup.+ myofibroblast-like cells. CD38 stimulation in immunodeficient mice reduced the wound size at the peak of neoangiogenesis and myofibroblast formation. In humans a corresponding cell population was identified, which was enriched in sprouting vessels of basal cell carcinoma biopsies. The results indicate that PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ vascular cells could proliferate and differentiate into myofibroblast-like cells in wound repair. Moreover, CD38 signaling modulates PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ cell activation in the healing process implying CD38 as a target for anti-angiogenic therapies in human basal cell carcinoma.</description><subject>Analysis</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Neovascularization</subject><subject>Wound care</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqN0FFLwzAQB_AgCs7pN_ChIAgi7ZqkTbvHUacONibbnI_jmiZbtiwZTQv67a1swgY-yMHdn_C7ewhCtzgMME1wZ23r0oAOdtaIIAxjShg5Qy3cpcRnJKTnR_kSXTm3_kEpYy1k3vpZb4QDV--Cx86Uw2_Mnmi6j94cHK81lF4mtHberATjpC23njKV9UZfVqq8tLkGV_lDtREHp4w33TTtw9am8CZiB6q8RhcStBM3h9lG78_9WfbqD8cvg6w39JeYsdgnRJCC0ghDykOAkBEgCU1yyaQA4EUeFQXlkOOcMyEpJRJHBY1A5EKKNEpoG93t7y5Bi4Uy0lYl8K1yfNGLkjSiOO7GjQr-UE0VYqt485lSNe8nCw8nC42pxGe1hNq5xWA6-b8dz0_t_ZFdCdDVylldV8oadwy_AehOlS4</recordid><startdate>20130104</startdate><enddate>20130104</enddate><creator>Etich, Julia</creator><creator>Bergmeier, Vera</creator><creator>Frie, Christian</creator><creator>Kreft, Sandra</creator><creator>Bengestrate, Lena</creator><creator>Eming, Sabine</creator><creator>Mauch, Cornelia</creator><creator>Eckes, Beate</creator><creator>Ulus, Hikmet</creator><creator>Lund, Frances E</creator><creator>Rappl, Gunter</creator><creator>Abken, Hinrich</creator><creator>Paulsson, Mats</creator><creator>Brachvogel, Bent</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20130104</creationdate><title>PECAM1.sup.+/Sca1.sup.+/CD38.sup.+ Vascular Cells Transform into Myofibroblast-Like Cells in Skin Wound Repair</title><author>Etich, Julia ; Bergmeier, Vera ; Frie, Christian ; Kreft, Sandra ; Bengestrate, Lena ; Eming, Sabine ; Mauch, Cornelia ; Eckes, Beate ; Ulus, Hikmet ; Lund, Frances E ; Rappl, Gunter ; Abken, Hinrich ; Paulsson, Mats ; Brachvogel, Bent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1665-22e2d3341a8c0aa062a2737bf6feaacdb4dd3cab1bc6ef332f14d34aebefe8473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Neovascularization</topic><topic>Wound care</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Etich, Julia</creatorcontrib><creatorcontrib>Bergmeier, Vera</creatorcontrib><creatorcontrib>Frie, Christian</creatorcontrib><creatorcontrib>Kreft, Sandra</creatorcontrib><creatorcontrib>Bengestrate, Lena</creatorcontrib><creatorcontrib>Eming, Sabine</creatorcontrib><creatorcontrib>Mauch, Cornelia</creatorcontrib><creatorcontrib>Eckes, Beate</creatorcontrib><creatorcontrib>Ulus, Hikmet</creatorcontrib><creatorcontrib>Lund, Frances E</creatorcontrib><creatorcontrib>Rappl, Gunter</creatorcontrib><creatorcontrib>Abken, Hinrich</creatorcontrib><creatorcontrib>Paulsson, Mats</creatorcontrib><creatorcontrib>Brachvogel, Bent</creatorcontrib><collection>Opposing Viewpoints In Context</collection><collection>Gale In Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Etich, Julia</au><au>Bergmeier, Vera</au><au>Frie, Christian</au><au>Kreft, Sandra</au><au>Bengestrate, Lena</au><au>Eming, Sabine</au><au>Mauch, Cornelia</au><au>Eckes, Beate</au><au>Ulus, Hikmet</au><au>Lund, Frances E</au><au>Rappl, Gunter</au><au>Abken, Hinrich</au><au>Paulsson, Mats</au><au>Brachvogel, Bent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PECAM1.sup.+/Sca1.sup.+/CD38.sup.+ Vascular Cells Transform into Myofibroblast-Like Cells in Skin Wound Repair</atitle><jtitle>PloS one</jtitle><date>2013-01-04</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e53262</spage><pages>e53262-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may also differentiate into matrix-secreting contractile myofibroblasts to promote wound closure. Here, we characterize a PECAM1.sup.+ /Sca1.sup.+ vascular cell population in mouse skin, which is highly enriched in wounds at the peak of neoangiogenesis and myofibroblast formation. These cells express endothelial and perivascular markers and present the receptor CD38 on their surface. PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ cells proliferate upon wounding and could give rise to [alpha]-SMA.sup.+ myofibroblast-like cells. CD38 stimulation in immunodeficient mice reduced the wound size at the peak of neoangiogenesis and myofibroblast formation. In humans a corresponding cell population was identified, which was enriched in sprouting vessels of basal cell carcinoma biopsies. The results indicate that PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ vascular cells could proliferate and differentiate into myofibroblast-like cells in wound repair. Moreover, CD38 signaling modulates PECAM1.sup.+ /Sca1.sup.+ /CD38.sup.+ cell activation in the healing process implying CD38 as a target for anti-angiogenic therapies in human basal cell carcinoma.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0053262</doi><tpages>e53262</tpages></addata></record> |
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| source | PLoS; Full-Text Journals in Chemistry (Open access); PubMed Central; Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Analysis Genetic aspects Health aspects Neovascularization Wound care |
| title | PECAM1.sup.+/Sca1.sup.+/CD38.sup.+ Vascular Cells Transform into Myofibroblast-Like Cells in Skin Wound Repair |
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