Epigenetic Regulation of BMP2 by 1,25-dihydroxyvitamin D.sub.3 through DNA Methylation and Histone Modification

Genetic hypercalciuric stone-forming (GHS) rats have increased intestinal Ca absorption, decreased renal tubule Ca reabsorption and low bone mass, all of which are mediated at least in part by elevated tissue levels of the vitamin D receptor (VDR). Both 1,25-dihydroxyvitamin D.sub.3 (1,25(OH).sub.2...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61423
Hauptverfasser:	Fu, Baisheng, Wang, Hongwei, Wang, Jinhua, Barouhas, Ivana, Liu, Wanqing, Shuboy, Adam, Bushinsky, David A, Zhou, Dongsheng, Favus, Murray J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone density Bone morphogenetic proteins DNA Epigenetic inheritance Genes Methylation Physiological aspects Sulfites Transcription (Genetics) Vitamin D
Online-Zugang:	Volltext
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