Structures of SHV-1 [beta]-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl Conjugation

Bacterial [beta]-lactamase enzymes are in large part responsible for the decreased ability of [beta]-lactam antibiotics to combat infections. The inability to overcome [beta]-lactamase mediated resistance spurred the development of inhibitors with penems and penam sulfones being amongst the most pot...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e49035
Hauptverfasser:	Ke, Wei, Pattanaik, Priyaranjan, Bethel, Christopher R, Sheri, Anjaneyulu, Buynak, John D, Bonomo, Robert A, van den Akker, Focco
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta lactamases Crystal structure Health aspects Lactams Microbial drug resistance Organic sulfur compounds
Online-Zugang:	Volltext
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