Restoration of Dioxin-Induced Damage to Fetal Steroidogenesis and Gonadotropin Formation by Maternal Co-Treatment with [alpha]-Lipoic Acid

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an endocrine disruptor, causes reproductive and developmental toxic effects in pups following maternal exposure in a number of animal models. Our previous studies have demonstrated that TCDD imprints sexual immaturity by suppressing the expression of fetal...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40322
Hauptverfasser:	Koga, Takayuki, Ishida, Takumi, Takeda, Tomoki, Ishii, Yuji, Uchi, Hiroshi, Tsukimori, Kiyomi, Yamamoto, Midori, Himeno, Masaru, Furue, Masutaka, Yamada, Hideyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antioxidants (Nutrients) Cytochrome P-450 Dioxins Gonadotropins Herbicides Organic acids Physiological aspects Pregnant women
Online-Zugang:	Volltext
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