Catenin Loss in Hepatocytes Promotes Hepatocellular Cancer after Diethylnitrosamine and Phenobarbital Administration to Mice

Hepatocellular Carcinoma (HCC) is the fifth most common cancer worldwide. [beta]-Catenin, the central orchestrator of the canonical Wnt pathway and a known oncogene is paramount in HCC pathogenesis. Administration of phenobarbital (PB) containing water (0.05% w/v) as tumor promoter following initial...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e39771
Hauptverfasser:	Awuah, Prince Kwaku, Rhieu, Byung Han, Singh, Sucha, Misse, Amalea, Monga, Satdarshan P. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cell death Central nervous system depressants Gene mutation Glutamine House mouse Liver cancer Phenobarbital Phosphotransferases Platelet-derived growth factor Tyrosine
Online-Zugang:	Volltext
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