TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-[kappa]B Signalling

K-Ras dependent non-small cell lung cancer (NSCLC) cells are 'addicted' to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner. Here we demonstrate that the xenophagy-associated kinase TBK1 drives basal autophagy, consistent with its known requirement in K-R...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50672
Hauptverfasser:	Newman, Alice C, Scholefield, Caroline L, Kemp, Alain J, Newman, Michelle, McIver, Edward G, Kamal, Ahmad, Wilkinson, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Non-small cell lung cancer Physiological aspects Protein binding
Online-Zugang:	Volltext
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