Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-[beta]1

Granzyme B (GrB) is a pro-apoptotic serine protease that contributes to immune-mediated target cell apoptosis. However, during inflammation, GrB accumulates in the extracellular space, retains its activity, and is capable of cleaving extracellular matrix (ECM) proteins. Recent studies have implicate...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33163
Hauptverfasser:	Boivin, Wendy A, Shackleford, Marlo, Vanden Hoek, Amanda, Zhao, Hongyan, Hackett, Tillie L, Knight, Darryl A, Granville, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bone morphogenetic proteins Cardiovascular diseases Inflammation Medical research Thrombin Transforming growth factors
Online-Zugang:	Volltext
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