Apoptotic Effects of Antilymphocyte Globulins on Human Pro-inflammatory CD4.sup.+CD28.sup.- T-cells

Apoptotic Effects of Antilymphocyte Globulins on Human Pro-inflammatory CD4.sup.+CD28.sup.- T-cells

Pro-inflammatory, cytotoxic CD4.sup.+ CD28.sup.- T-cells with known defects in apoptosis have been investigated as markers of premature immuno-senescence in various immune-mediated diseases. In this study we evaluated the influence of polyclonal antilymphocyte globulins (ATG-Fresenius, ATG-F) on CD4...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2012-03, Vol.7 (3), p.e33939
Hauptverfasser: Duftner, Christina, Dejaco, Christian, Hengster, Paul, Bijuklic, Klaudija, Joannidis, Michael, Margreiter, Raimund, Schirmer, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Apoptosis
Blood proteins
Medical research
T cells
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 3
container_start_page e33939
container_title PloS one
container_volume 7
creator Duftner, Christina
Dejaco, Christian
Hengster, Paul
Bijuklic, Klaudija
Joannidis, Michael
Margreiter, Raimund
Schirmer, Michael
description Pro-inflammatory, cytotoxic CD4.sup.+ CD28.sup.- T-cells with known defects in apoptosis have been investigated as markers of premature immuno-senescence in various immune-mediated diseases. In this study we evaluated the influence of polyclonal antilymphocyte globulins (ATG-Fresenius, ATG-F) on CD4.sup.+ CD28.sup.- T-cells in vivo and in vitro. In summary, in vivo depletion of peripheral CD3.sup.+ CD4.sup.+ CD28.sup.- T-cells by ATG-F in transplant recipients was paralleled in vitro by ATG-F induced apoptosis. CD25 expression and chemokine receptor down-regulation in CD4.sup.+ CD28.sup.- T-cells only partly explain the underlying mechanism.
doi_str_mv 10.1371/journal.pone.0033939
format Article
fullrecord <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A476993875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A476993875</galeid><sourcerecordid>A476993875</sourcerecordid><originalsourceid>FETCH-LOGICAL-g1665-255df844066046c5ac0bcd99633705134a829cb3c908742b6d7591cd072673063</originalsourceid><addsrcrecordid>eNqNkFFLwzAUhYMoOKf_wIeCIIi0pk2TNI-lm9tgMNHp60jTdMtIk9Kk4P69RX3YwAe5D_dw73cOlwvAbQyjGNH4aW_7znAdtdbICEKEGGJnYBQzlIQkgej8SF-CK-f2EGKUETICIm9t661XIpjWtRTeBbYOcuOVPjTtzoqDl8FM27LXygw7E8z7hpvgpbOhMrXmTcO97Q5BMUkj17fRYzFJsm8VButQSK3dNbiouXby5rePwfvzdF3Mw-VqtijyZbiNCcFhgnFVZ2kKCYEpEZgLWIqKMYIQhThGKc8SJkokGMxompSkopjFooI0IRRBgsbg7id3y7XcDNdZ33HRKCc2eUoJYyijeKCiP6ihKtkoMXywVsP8xPBwYhgYLz_9lvfObRZvr_9nVx-n7P0Ru5Nc-52zuvfKGncMfgHsEpAH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Apoptotic Effects of Antilymphocyte Globulins on Human Pro-inflammatory CD4.sup.+CD28.sup.- T-cells</title><source>PLoS</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Duftner, Christina ; Dejaco, Christian ; Hengster, Paul ; Bijuklic, Klaudija ; Joannidis, Michael ; Margreiter, Raimund ; Schirmer, Michael</creator><creatorcontrib>Duftner, Christina ; Dejaco, Christian ; Hengster, Paul ; Bijuklic, Klaudija ; Joannidis, Michael ; Margreiter, Raimund ; Schirmer, Michael</creatorcontrib><description>Pro-inflammatory, cytotoxic CD4.sup.+ CD28.sup.- T-cells with known defects in apoptosis have been investigated as markers of premature immuno-senescence in various immune-mediated diseases. In this study we evaluated the influence of polyclonal antilymphocyte globulins (ATG-Fresenius, ATG-F) on CD4.sup.+ CD28.sup.- T-cells in vivo and in vitro. In summary, in vivo depletion of peripheral CD3.sup.+ CD4.sup.+ CD28.sup.- T-cells by ATG-F in transplant recipients was paralleled in vitro by ATG-F induced apoptosis. CD25 expression and chemokine receptor down-regulation in CD4.sup.+ CD28.sup.- T-cells only partly explain the underlying mechanism.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0033939</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Analysis ; Apoptosis ; Blood proteins ; Medical research ; T cells</subject><ispartof>PloS one, 2012-03, Vol.7 (3), p.e33939</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids></links><search><creatorcontrib>Duftner, Christina</creatorcontrib><creatorcontrib>Dejaco, Christian</creatorcontrib><creatorcontrib>Hengster, Paul</creatorcontrib><creatorcontrib>Bijuklic, Klaudija</creatorcontrib><creatorcontrib>Joannidis, Michael</creatorcontrib><creatorcontrib>Margreiter, Raimund</creatorcontrib><creatorcontrib>Schirmer, Michael</creatorcontrib><title>Apoptotic Effects of Antilymphocyte Globulins on Human Pro-inflammatory CD4.sup.+CD28.sup.- T-cells</title><title>PloS one</title><description>Pro-inflammatory, cytotoxic CD4.sup.+ CD28.sup.- T-cells with known defects in apoptosis have been investigated as markers of premature immuno-senescence in various immune-mediated diseases. In this study we evaluated the influence of polyclonal antilymphocyte globulins (ATG-Fresenius, ATG-F) on CD4.sup.+ CD28.sup.- T-cells in vivo and in vitro. In summary, in vivo depletion of peripheral CD3.sup.+ CD4.sup.+ CD28.sup.- T-cells by ATG-F in transplant recipients was paralleled in vitro by ATG-F induced apoptosis. CD25 expression and chemokine receptor down-regulation in CD4.sup.+ CD28.sup.- T-cells only partly explain the underlying mechanism.</description><subject>Analysis</subject><subject>Apoptosis</subject><subject>Blood proteins</subject><subject>Medical research</subject><subject>T cells</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkFFLwzAUhYMoOKf_wIeCIIi0pk2TNI-lm9tgMNHp60jTdMtIk9Kk4P69RX3YwAe5D_dw73cOlwvAbQyjGNH4aW_7znAdtdbICEKEGGJnYBQzlIQkgej8SF-CK-f2EGKUETICIm9t661XIpjWtRTeBbYOcuOVPjTtzoqDl8FM27LXygw7E8z7hpvgpbOhMrXmTcO97Q5BMUkj17fRYzFJsm8VButQSK3dNbiouXby5rePwfvzdF3Mw-VqtijyZbiNCcFhgnFVZ2kKCYEpEZgLWIqKMYIQhThGKc8SJkokGMxompSkopjFooI0IRRBgsbg7id3y7XcDNdZ33HRKCc2eUoJYyijeKCiP6ihKtkoMXywVsP8xPBwYhgYLz_9lvfObRZvr_9nVx-n7P0Ru5Nc-52zuvfKGncMfgHsEpAH</recordid><startdate>20120330</startdate><enddate>20120330</enddate><creator>Duftner, Christina</creator><creator>Dejaco, Christian</creator><creator>Hengster, Paul</creator><creator>Bijuklic, Klaudija</creator><creator>Joannidis, Michael</creator><creator>Margreiter, Raimund</creator><creator>Schirmer, Michael</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20120330</creationdate><title>Apoptotic Effects of Antilymphocyte Globulins on Human Pro-inflammatory CD4.sup.+CD28.sup.- T-cells</title><author>Duftner, Christina ; Dejaco, Christian ; Hengster, Paul ; Bijuklic, Klaudija ; Joannidis, Michael ; Margreiter, Raimund ; Schirmer, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1665-255df844066046c5ac0bcd99633705134a829cb3c908742b6d7591cd072673063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analysis</topic><topic>Apoptosis</topic><topic>Blood proteins</topic><topic>Medical research</topic><topic>T cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duftner, Christina</creatorcontrib><creatorcontrib>Dejaco, Christian</creatorcontrib><creatorcontrib>Hengster, Paul</creatorcontrib><creatorcontrib>Bijuklic, Klaudija</creatorcontrib><creatorcontrib>Joannidis, Michael</creatorcontrib><creatorcontrib>Margreiter, Raimund</creatorcontrib><creatorcontrib>Schirmer, Michael</creatorcontrib><collection>Gale in Context : Opposing Viewpoints</collection><collection>Gale in Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duftner, Christina</au><au>Dejaco, Christian</au><au>Hengster, Paul</au><au>Bijuklic, Klaudija</au><au>Joannidis, Michael</au><au>Margreiter, Raimund</au><au>Schirmer, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptotic Effects of Antilymphocyte Globulins on Human Pro-inflammatory CD4.sup.+CD28.sup.- T-cells</atitle><jtitle>PloS one</jtitle><date>2012-03-30</date><risdate>2012</risdate><volume>7</volume><issue>3</issue><spage>e33939</spage><pages>e33939-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Pro-inflammatory, cytotoxic CD4.sup.+ CD28.sup.- T-cells with known defects in apoptosis have been investigated as markers of premature immuno-senescence in various immune-mediated diseases. In this study we evaluated the influence of polyclonal antilymphocyte globulins (ATG-Fresenius, ATG-F) on CD4.sup.+ CD28.sup.- T-cells in vivo and in vitro. In summary, in vivo depletion of peripheral CD3.sup.+ CD4.sup.+ CD28.sup.- T-cells by ATG-F in transplant recipients was paralleled in vitro by ATG-F induced apoptosis. CD25 expression and chemokine receptor down-regulation in CD4.sup.+ CD28.sup.- T-cells only partly explain the underlying mechanism.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0033939</doi><tpages>e33939</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2012-03, Vol.7 (3), p.e33939
issn 1932-6203
1932-6203
language eng
recordid cdi_gale_infotracmisc_A476993875
source PLoS; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library
subjects Analysis
Apoptosis
Blood proteins
Medical research
T cells
title Apoptotic Effects of Antilymphocyte Globulins on Human Pro-inflammatory CD4.sup.+CD28.sup.- T-cells
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T18%3A40%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Apoptotic%20Effects%20of%20Antilymphocyte%20Globulins%20on%20Human%20Pro-inflammatory%20CD4.sup.+CD28.sup.-%20T-cells&rft.jtitle=PloS%20one&rft.au=Duftner,%20Christina&rft.date=2012-03-30&rft.volume=7&rft.issue=3&rft.spage=e33939&rft.pages=e33939-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0033939&rft_dat=%3Cgale%3EA476993875%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A476993875&rfr_iscdi=true