Pre-Fibrillar [alpha]-Synuclein Mutants Cause Parkinson's Disease-Like Non-Motor Symptoms in Drosophila

Parkinson's disease (PD) is linked to the formation of insoluble fibrillar aggregates of the presynaptic protein [alpha]-Synuclein ([alpha]S) in neurons. The appearance of such aggregates coincides with severe motor deficits in human patients. These deficits are often preceded by non-motor symp...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24701
Hauptverfasser:	Gajula Balija, Madhu Babu, Griesinger, Christian, Herzig, Alf, Zweckstetter, Markus, Jäckle, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cell death Drosophila Neurophysiology Sleep
Online-Zugang:	Volltext
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