Identification of Epidermal Pdx1 Expression Discloses Different Roles of Notch1 and Notch2 in Murine Kras.sup.G12D-Induced Skin Carcinogenesis In Vivo

The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis. To study the role of Notch and oncogenic Kras signaling in a progenitor cell population, Pdx1-Cre mice were utilized to generat...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e13578
Hauptverfasser:	Mazur, Pawel K, Grüner, Barbara M, Nakhai, Hassan, Sipos, Bence, Zimber-Strobl, Ursula, Strobl, Lothar J, Radtke, Freddy, Schmid, Roland M, Siveke, Jens T
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation (Surgery) Analysis Development and progression Genetic engineering Skin Skin cancer Squamous cell carcinoma
Online-Zugang:	Volltext
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